Synthesis and characterization of nanostructured lipid nanocarriers for enhanced sun protection factor of octyl p-methoxycinnamate

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorFederal University of Ceará-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorPrado, Alice Haddad Do [UNESP]-
Autor(es): dc.creatorAraújo, Victor Hugo Sousa [UNESP]-
Autor(es): dc.creatorEloy, Josimar O.-
Autor(es): dc.creatorFonseca-Santos, Bruno [UNESP]-
Autor(es): dc.creatorPereira-Da-Silva, Marcelo A.-
Autor(es): dc.creatorPeccinini, Rosângela Gonçalves [UNESP]-
Autor(es): dc.creatorChorilli, Marlus [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:34:20Z-
Data de disponibilização: dc.date.available2022-02-22T00:34:20Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1208/s12249-019-1547-0-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201726-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201726-
Descrição: dc.descriptionSunlight is important to health, but higher exposure to radiation causes early aging of the skin and skin damage that can lead to skin cancers. This study aimed at producing a stable octyl p-methoxycinnamate (OMC)–loaded nanostructured lipid carrier (NLC) sunscreen, which can help in the photoprotective effect. NLC was produced by emulsification-sonication method and these systems were composed of myristyl myristate (MM), caprylic capric triglyceride (CCT), Tween® 80 (TW), and soybean phosphatidylcho-line (SP) and characterized by dynamic light scattering (DLS), zeta potential (ZP) measurement, atomic force microscopy (AFM), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and in vitro release studies. Pre-formulation studies were performed changing TW concentrations and no differences were found at concentrations of 1.0 and 2.0%. Two selected formulations were designed and showed an average size of 91.5–131.7, polydispersity index > 0.2, and a negative value of ZP. AFM presented a sphere-like morphology and SEM showed ability to form a thin film. DSC exhibited that the incorporation of OMC promoted reduction of enthalpy due to formation of a more amorphous structure. Drug release shows up to 55.74% and 30.57%, and this difference could be related to the presence of SP in this formulation that promoted a more amorphous structure; the release mechanism study indicated Fickian diffusion and relaxation. Sun protection factor (SPF) evaluation was performed using NLC and presented values around 40, considerably higher than those observed in the literature. The developed formulations provide a beneficial alternative to conventional sunscreen formulations.-
Descrição: dc.descriptionUniversidade Estadual Paulista-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences UNESP-São Paulo State Uni-versity, Rodovia Araraquara-Jau, km. 1-
Descrição: dc.descriptionDepartment of Pharmacy School of Pharmacy Odontology and Nursing Federal University of Ceará-
Descrição: dc.descriptionInstitute of Physics of São Carlos University of São Paulo-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences UNESP-São Paulo State Uni-versity, Rodovia Araraquara-Jau, km. 1-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2014/22426-2-
Idioma: dc.languageen-
Relação: dc.relationAAPS PharmSciTech-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDrug release-
Palavras-chave: dc.subjectDS: Octyl p-methoxycinnamate-
Palavras-chave: dc.subjectNanostructured lipid carrier-
Palavras-chave: dc.subjectSun protection factor-
Palavras-chave: dc.subjectSunscreen-
Título: dc.titleSynthesis and characterization of nanostructured lipid nanocarriers for enhanced sun protection factor of octyl p-methoxycinnamate-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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