Poloxamer micellar system for intra-articular injection of 15-deoxy-Δ12,14-prostaglandin J2 with improved bioavailability and anti-inflammatory properties in the temporomandibular joint of rats

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorLaboratory of Neuroimmune Interface of Pain-
Autor(es): dc.contributorFaculdade São Leopoldo Mandic de Araras-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorFederal University of ABC-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorAbdalla, Henrique B.-
Autor(es): dc.creatorNapimoga, Marcelo H.-
Autor(es): dc.creatorMacedo, Cristina G.-
Autor(es): dc.creatorBonfante, Ricardo-
Autor(es): dc.creatorDe Araujo, Daniele.R.-
Autor(es): dc.creatorde Mello, Nathalie F.S.-
Autor(es): dc.creatorCarvalho, Lucas B. [UNESP]-
Autor(es): dc.creatorFraceto, Leonardo F. [UNESP]-
Autor(es): dc.creatorClemente-Napimoga, Juliana T.-
Data de aceite: dc.date.accessioned2022-02-22T00:34:20Z-
Data de disponibilização: dc.date.available2022-02-22T00:34:20Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-06-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ijpharm.2020.119383-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201725-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201725-
Descrição: dc.descriptionPainful conditions of the temporomandibular joint (TMJ) are challenging to manage and most attempts often result in unsatisfactory outcomes. In such context, nanocarrier systems, such as polymeric micelles, have been showing encouraging results in solving therapeutic limitations. Poloxamers are widely used, especially PL 407, because of their high biocompatibility and approval by the Food and Drug Administration (FDA) for clinical use. 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) has shown important antinociceptive and anti-inflammatory activity. The present study evaluated the efficacy and viability of the micellar system of PL-15dPGJ2 in a formalin-induced acute pain model in the temporomandibular joint of rats. The PL-15dPGJ2 was prepared and characterized. The animals were pretreated with an intra-articular injection of PL-15dPGJ2 followed by the formalin challenge. The nociceptive response was evaluated at different time-periods and the periarticular tissue and articular wash were collected for analysis. We found that intra-articular injection of PL-15d-PGJ2 produced pain relief at lower concentrations and in a sustained manner compared with free 15d-PGJ2. Moreover, a strong anti-inflammatory effect was observed with decreased levels of key pro-inflammatory cytokines and modulation of the leukocyte migration process. Our findings suggest that 15d-PGJ2 combined with a poloxamer micellar system provided clinical relevance in terms of bioavailability, long-lasting effect, and safe dosage. The formulation investigated herein is a promising micellar carrier system for managing pain conditions of the TMJ.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDrug Research Academy, Københavns Universitet-
Descrição: dc.descriptionLefkofsky Family Foundation-
Descrição: dc.descriptionFaculdade São Leopoldo Mandic Instituto São Leopoldo Mandic Laboratory of Neuroimmune Interface of Pain-
Descrição: dc.descriptionFaculdade São Leopoldo Mandic de Araras-
Descrição: dc.descriptionDepartment of Physiology Sciences Piracicaba Dental School University of Campinas-
Descrição: dc.descriptionCenter of Human and Natural Sciences Federal University of ABC-
Descrição: dc.descriptionDepartment of Environmental Engineering São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Environmental Engineering São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Pharmaceutics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject15d-PGJ2-
Palavras-chave: dc.subjectPain-
Palavras-chave: dc.subjectPoloxamer micellar system-
Palavras-chave: dc.subjectTemporomandibular joint-
Título: dc.titlePoloxamer micellar system for intra-articular injection of 15-deoxy-Δ12,14-prostaglandin J2 with improved bioavailability and anti-inflammatory properties in the temporomandibular joint of rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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