Machaerium hirtum (Vell.) stellfeld alleviates acute pain and inflammation: Potential mechanisms of action

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Federal de Santa Catarina (UFSC)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorAgostinho Lopes, Juliana [UNESP]-
Autor(es): dc.creatorPeixoto Rodrigues, Vinícius [UNESP]-
Autor(es): dc.creatorMarucci Pereira Tangerina, Marcelo [UNESP]-
Autor(es): dc.creatorMachado Da Rocha, Lucia Regina [UNESP]-
Autor(es): dc.creatorMassucato Nishijima, Catarine-
Autor(es): dc.creatorAlfieri Nunes, Vania Vasti [UNESP]-
Autor(es): dc.creatorRolim De Almeida, Luiz Fernando [UNESP]-
Autor(es): dc.creatorVilegas, Wagner [UNESP]-
Autor(es): dc.creatorSoares Dos Santos, Adair Roberto-
Autor(es): dc.creatorSannomiya, Miriam-
Autor(es): dc.creatorHiruma-Lima, Clélia Akiko [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:34:14Z-
Data de disponibilização: dc.date.available2022-02-22T00:34:14Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/biom10040590-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201689-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201689-
Descrição: dc.descriptionMachaerium hirtum (Vell.) Stellfeld (Fabaceae) known in Brazil as “jacaranda de espinho” or “espinheira santa nativa” is a medicinal plant commonly used in folk medicine to treat ulcers, cough and diarrhea. This study aimed to investigate the anti-inflammatory and antinociceptive effects of hydroalcoholic extracts from M. hirtum twig (HEMh) using in vivo experimental models of nociception through the involvement of transient receptor potential channels, acid-sensing ion channel (ASIC), nitrergic, opioidergic, glutamatergic, and supraspinal pathways. Our results revealed an antinociceptive effect of HEMh mediated by the opioidergic, L-arginine-nitric oxide and glutamate systems, as well as by interactions with TRPA1/ASIC channels. The anti-inflammatory effect of HEMh evaluated with a xylene-induced ear edema and by the involvement of arachidonic acid and prostaglandin E2 (PGE2) showed involvement of the COX pathway, based on observed decreases in PGE2 levels. A phytochemical investigation of the HEMh led to the isolation of α- amyrin, β-amyrin, allantoin, apigenin-7-methoxy-6-C-β-D-glucopyranoside, and apigenin-6-C-β-Dglucopyranosyl- 8-C-β-D-xylopyranoside. In conclusion, the acute oral administration of HEMh inhibits the nociceptive behavioral response in animals through the nitrergic, opioid, glutamatergic pathways, and by inhibition of the TRPA1 and ASIC channels, without causing locomotor dysfunction. In addition, its anti-inflammatory effect is associated with the COX pathway and decreased PGE2 levels.-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Physiology São Paulo State University UNESP Institute of Biosciences-
Descrição: dc.descriptionCoastal Campus São Paulo State University UNESP-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biology State University of Campinas UNICAMP-
Descrição: dc.descriptionBotany Department São Paulo State University UNESP Biosciences Institute-
Descrição: dc.descriptionLaboratory of Neurobiology of Pain and Inflammation Department of Physiological Sciences Central of Biological Sciences Federal University of Santa Catarina Trindade Florianopolis-
Descrição: dc.descriptionSchool of Arts Sciences and Humanities São Paulo University USP-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Physiology São Paulo State University UNESP Institute of Biosciences-
Descrição: dc.descriptionCoastal Campus São Paulo State University UNESP-
Descrição: dc.descriptionBotany Department São Paulo State University UNESP Biosciences Institute-
Idioma: dc.languageen-
Relação: dc.relationBiomolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAnti-inflammatory action-
Palavras-chave: dc.subjectAntinociceptive effect-
Palavras-chave: dc.subjectMachaerium hirtum-
Título: dc.titleMachaerium hirtum (Vell.) stellfeld alleviates acute pain and inflammation: Potential mechanisms of action-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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