A Review of Properties, Delivery Systems and Analytical Methods for the Characterization of Monomeric Glycoprotein Transferrin

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorState University of Paraíba-
Autor(es): dc.contributorFederal University of Ceara (UFC)-
Autor(es): dc.creatorFernandes, Mariza Aires [UNESP]-
Autor(es): dc.creatorHanck-Silva, Gilmar [UNESP]-
Autor(es): dc.creatorBaveloni, Franciele Garcia [UNESP]-
Autor(es): dc.creatorOshiro Junior, João Augusto-
Autor(es): dc.creatorde Lima, Felipe Tita [UNESP]-
Autor(es): dc.creatorEloy, Josimar O.-
Autor(es): dc.creatorChorilli, Marlus [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:34:09Z-
Data de disponibilização: dc.date.available2022-02-22T00:34:09Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/10408347.2020.1743639-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201654-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201654-
Descrição: dc.descriptionTransferrin is a protein involved in iron uptake by cells and has been identified as a potential target for directing drug-loaded nanoparticles for cancer treatment and diagnosis. Most methods for conjugation of transferrin and nanoparticles involve the formation of a thioeter bond between thiolated transferrin and maleimide-containing nanoparticle. For nanoparticle development, it is important to perform a thorough physicochemical characterization, including quantification of the amount of transferrin functionalizing the delivery system. Thus, following the transferrin and nanoparticle chemical conjugation, an analytical method is need for transferrin quantification. Altogether, we revised both physicochemical and pharmacokinetics transferrin characteristics, the aspects of iron transport after interaction with transferrin, the development of transferrin targeted-nanoparticles, highlighting both their composition, synthesis methods and in vitro/in vivo evaluation. Furthermore, we addressed the analytical methods employed in protein quantification, including spectrophotometric/colorimetric, immunoassays, electrophoretic and chromatographic techniques used to identify and/or quantify of transferrin in biological matrices and drug delivery systems.-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionCenter of Biological and Health Sciences State University of Paraíba-
Descrição: dc.descriptionCollege of Pharmacy Dentistry and Nursing Federal University of Ceara (UFC)-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationCritical Reviews in Analytical Chemistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectanalytical methods-
Palavras-chave: dc.subjectdrug delivery systems-
Palavras-chave: dc.subjectmonomeric glycoprotein-
Palavras-chave: dc.subjectphysicochemical characteristics-
Palavras-chave: dc.subjectTransferrin-
Título: dc.titleA Review of Properties, Delivery Systems and Analytical Methods for the Characterization of Monomeric Glycoprotein Transferrin-
Aparece nas coleções:Repositório Institucional - Unesp

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