Renovascular hypertension elevates pulmonary ventilation in rats by carotid body-dependent mechanisms

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.creatorMelo, Mariana Rosso [UNESP]-
Autor(es): dc.creatorGasparini, Silvia [UNESP]-
Autor(es): dc.creatorSilva, Elaine F. [UNESP]-
Autor(es): dc.creatorKarlen-Amarante, Marlusa [UNESP]-
Autor(es): dc.creatorSperetta, Guilherme F. [UNESP]-
Autor(es): dc.creatorLauar, Mariana R. [UNESP]-
Autor(es): dc.creatorPedrino, Gustavo R.-
Autor(es): dc.creatorMenani, Jose V. [UNESP]-
Autor(es): dc.creatorColombari, Debora S.A. [UNESP]-
Autor(es): dc.creatorZoccal, Daniel B. [UNESP]-
Autor(es): dc.creatorColombari, Eduardo [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:34:07Z-
Data de disponibilização: dc.date.available2022-02-22T00:34:07Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1152/AJPREGU.00134.2019-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201644-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201644-
Descrição: dc.descriptionThe two kidney-one clip (2K1C) renovascular hypertension depends on the renin-angiotensin system and sympathetic overactivity. The maintenance of 2K1C hypertension also depends on inputs from the carotid bodies (CB), which when activated stimulate the respiratory activity. In the present study, we investigated the importance of CB afferent activity for the ventilatory responses in 2K1C hypertensive rats and for phrenic and hypoglossal activities in in situ preparations of normotensive rats treated with angiotensin II. Silver clips were implanted around the left renal artery of male Holtzman rats (150 g) to induce renovascular hypertension. Six weeks after clipping, hypertensive 2K1C rats showed, in conscious state, elevated resting tidal volume and minute ventilation compared with the normotensive group. 2K1C rats also presented arterial alkalosis, urinary acidification, and amplified hypoxic ventilatory response. Carotid body removal (CBR), 2 wk before the experiments (4th week after clipping), significantly reduced arterial pressure and pulmonary ventilation in 2K1C rats but not in normotensive rats. Intra-arterial administration of angiotensin II in the in situ preparation of normotensive rats increased phrenic and hypoglossal activities, responses that were also reduced after CBR. Results show that renovascular hypertensive rats exhibit increased resting ventilation that depends on CB inputs. Similarly, angiotensin II increases phrenic and hypoglossal activities in in situ preparations of normotensive rats, responses that also depend on CB inputs. Results suggest that mechanisms that depend on CB inputs in renovascular hypertensive rats or during angiotensin II administration in normotensive animals increase respiratory drive.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry São Paulo State University (UNESP), Rua Humaitá, 1680-
Descrição: dc.descriptionCenter for Neuroscience and Cardiovascular Research Department of Physiological Sciences Biological Sciences Institute Federal University of Goiás-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry São Paulo State University (UNESP), Rua Humaitá, 1680-
Descrição: dc.descriptionFAPESP: 2013/17.251-6-
Descrição: dc.descriptionFAPESP: 2014/01159-6-
Descrição: dc.descriptionFAPESP: 2015/23467-7-
Descrição: dc.descriptionCNPq: 310331/ 2017-0-
Descrição: dc.descriptionCNPq: 449392/2014-7-
Formato: dc.formatR730-R742-
Idioma: dc.languageen-
Relação: dc.relationAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAngiotensin-
Palavras-chave: dc.subjectCarotid body-
Palavras-chave: dc.subjectRenovascular hypertension-
Palavras-chave: dc.subjectRespiration-
Título: dc.titleRenovascular hypertension elevates pulmonary ventilation in rats by carotid body-dependent mechanisms-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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