The role of stabilizers and mechanical processes on physico-chemical and anti-inflammatory properties of methotrexate nanosuspensions

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorSantos, Aline Martins dos [UNESP]-
Autor(es): dc.creatorMeneguin, Andréia Bagliotti [UNESP]-
Autor(es): dc.creatorFonseca-Santos, Bruno [UNESP]-
Autor(es): dc.creatorChaves de Souza, Maurício Palmeira [UNESP]-
Autor(es): dc.creatorBarboza Ferreira, Leonardo Miziara [UNESP]-
Autor(es): dc.creatorSábio, Rafael Miguel [UNESP]-
Autor(es): dc.creatorChorilli, Marlus [UNESP]-
Autor(es): dc.creatorDaflon Gremião, Maria Palmira [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:34:02Z-
Data de disponibilização: dc.date.available2022-02-22T00:34:02Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jddst.2020.101638-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201629-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201629-
Descrição: dc.descriptionThe aim of this study was to investigate two different mechanical processes (Ultra-turrax® and Sonication) and two stabilizers (Methyl cellulose (MC) and Poloxamer 407 (P407)) on the physico-chemical and anti-inflammatory properties of the MTX nanosuspensions. The mechanical process, presence and type of stabilizers showed a strong impact on the particle size, polydispersity index (PDI), zeta potential and morphology of MTX nanosuspensions. In particular, the surfactant property of P407 in combination sonication process reduced significantly the particle size of MTX to nano-range size. Short term stability evaluated by dynamic light scattering (DLS) technique proved that the addition of the stabilizers MC and P407 on the MTX nanosuspensions provided stability through of the steric hindrance. In vitro dissolution studies showed that MTX nanosuspensions enhanced the drug release rates, revealing the influence of the different particle size on the drug release profiles. In vivo inflammation study indicated that MTX nanosuspensions presented a greater effect on the anti-inflammatory activity, maintaining this effect for up to 6 h, being more effective than the positive control. It could be concluded that the combined usage of mechanical processes and stabilizers modified in vitro and in vivo performance of the MTX nanosuspensions. Therefore, these results confirm the potential of these nanosuspensions as a promising tool for enhancement of dissolution rate and oral bioavailability of poorly water-soluble drugs, such as MTX.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2016/01464-9-
Idioma: dc.languageen-
Relação: dc.relationJournal of Drug Delivery Science and Technology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAcid-base neutralization-
Palavras-chave: dc.subjectAnti-inflammatory activity-
Palavras-chave: dc.subjectBottom-up process-
Palavras-chave: dc.subjectMethotrexate-
Palavras-chave: dc.subjectMethyl cellulose-
Palavras-chave: dc.subjectNanosuspension-
Palavras-chave: dc.subjectPoloxamer 407-
Título: dc.titleThe role of stabilizers and mechanical processes on physico-chemical and anti-inflammatory properties of methotrexate nanosuspensions-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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