A new synthetic methodology for pyridinic sucrose esters and their antibacterial effects against Gram-positive and Gram-negative strains

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorFacultad de Ciencias Basicas-
Autor(es): dc.creatorMora Vargas, Jorge Andrés [UNESP]-
Autor(es): dc.creatorOrtega, Julieth Orduña [UNESP]-
Autor(es): dc.creatordos Santos, Maitê Bernardo Correia [UNESP]-
Autor(es): dc.creatorMetzker, Gustavo [UNESP]-
Autor(es): dc.creatorGomes, Eleni [UNESP]-
Autor(es): dc.creatorBoscolo, Mauricio [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:33:54Z-
Data de disponibilização: dc.date.available2022-02-22T00:33:54Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.carres.2020.107957-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201575-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201575-
Descrição: dc.descriptionDescribed are the development of a new synthetic method using ultrasonic irradiation and sodium methoxide as catalyst for a series of pyridinic sucrose esters (py-SEs), derived from transesterification of sucrose with picolinic, nicotinic and isonicotinic methyl esters. The reaction was optimized using a 32 x 2 experimental design, the reaction time, temperature and sucrose: methyl ester molar ratio being evaluated. The method proved to be efficient for obtaining monosubstituted esters (≥83%) with high methyl ester consumption (≥79%). The monosubstituted py-SEs were isolated by semipreparative HPLC, characterized by high-resolution mass spectrometry, calorimetry, vibrational spectroscopy, and 1H and 13C NMR. The py-SEs were tested against E. coli, S. aureos, and P. aeruginosa bacteria with minimum inhibitory concentration values equal or inferior to the reference drugs for both E. coli and P. aeruginosa.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionSao Paulo State University (UNESP) Institute of Biosciences Humanities and Exact Sciences, Sao Jose do Rio Preto, SP-
Descrição: dc.descriptionUniversidad Santiago de Cali Facultad de Ciencias Basicas Campus Pampalinda-
Descrição: dc.descriptionSao Paulo State University (UNESP) Institute of Biosciences Humanities and Exact Sciences, Sao Jose do Rio Preto, SP-
Descrição: dc.descriptionCNPq: 140035/2019-2-
Descrição: dc.descriptionCAPES: PNPD 1760327-
Idioma: dc.languageen-
Relação: dc.relationCarbohydrate Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAcoustic cavitation-
Palavras-chave: dc.subjectAntibacterial activity-
Palavras-chave: dc.subjectHomogeneous catalysis-
Palavras-chave: dc.subjectPyridinic methyl esters-
Palavras-chave: dc.subjectucrose esters-
Título: dc.titleA new synthetic methodology for pyridinic sucrose esters and their antibacterial effects against Gram-positive and Gram-negative strains-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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