Effects of isolated or combined exposure to sibutramine and rosuvastatin on reproductive parameters of adult male rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUS Environmental Protection Agency-
Autor(es): dc.creatore Silva, Patrícia Villela [UNESP]-
Autor(es): dc.creatorBorges, Cibele dos Santos [UNESP]-
Autor(es): dc.creatorRosa, Josiane de Lima [UNESP]-
Autor(es): dc.creatorPacheco, Tainá Louise [UNESP]-
Autor(es): dc.creatorFigueiredo, Thamiris Moreira [UNESP]-
Autor(es): dc.creatorLeite, Gabriel Adan Araújo-
Autor(es): dc.creatorGuerra, Marina Trevizan [UNESP]-
Autor(es): dc.creatorAnselmo-Franci, Janete Aparecida-
Autor(es): dc.creatorKlinefelter, Gary Robert-
Autor(es): dc.creatorKempinas, Wilma De Grava [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:33:53Z-
Data de disponibilização: dc.date.available2022-02-22T00:33:53Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/jat.3955-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201568-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201568-
Descrição: dc.descriptionMany obese patients are exposed to hypolipidemic and serotonin-norepinephrine reuptake inhibitor (SNRI) drugs. Statins are one of the most marketed drugs in the world to treat dyslipidemia, while sibutramine, a SNRI drug, is prescribed in some countries to treat obesity and is detected as an additive in many adulterated weight loss supplements marketed worldwide. Previous studies reported adverse effects of isolated exposure to these drugs on male rat reproductive parameters. In the present work, we further investigated male reproductive toxicity of these drugs, administered in isolation or combination in adult rats for a longer period of treatment. Adult male rats (90 days) were treated (gavage) for 70 days with saline and dimethyl sulfoxide (control), sibutramine (10 mg/kg), rosuvastatin (5 mg/kg), or rosuvastatin combined with sibutramine. Sibutramine alone or with rosuvastatin, promoted a reduction in food intake and body weight gain, weight of the epididymis, ventral prostate and seminal vesicle; as well as decreased sperm reserves and transit time through the epididymis; androgen depletion; and increased index of cytoplasmic droplet. The rosuvastatin-treated group showed reduced frequency of ejaculation. Exposure to this drug alone or combined with sibutramine impaired epididymal morphology. Co-exposed rats had altered epididymal morphometry, and seminal vesicle and testis weights. The rats also showed decreased fertility after natural mating and a trend toward a delay in ejaculation, suggesting a small synergistic effect of these drugs. Given the greater reproductive efficiency of rodents, the results obtained in the present study raise concern regarding possible fertility impairment in men taking statins and SNRI drugs.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Morphology Institute of Biosciences São Paulo State University - UNESP-
Descrição: dc.descriptionGraduate Program in Cell and Structural Biology Institute of Biology State University of Campinas – UNICAMP-
Descrição: dc.descriptionDepartment of Morphology Physiology and Basic Pathology School of Dentistry of Ribeirão Preto University of São Paulo – USP-
Descrição: dc.descriptionReproductive Toxicity Branch Toxicity Assessment Division National Health and Environmental Effects Research Laboratory Office of Research and Development US Environmental Protection Agency-
Descrição: dc.descriptionDepartment of Morphology Institute of Biosciences São Paulo State University - UNESP-
Descrição: dc.descriptionFAPESP: 2014/15566-2-
Descrição: dc.descriptionCNPq: 308842/2013-8-
Descrição: dc.descriptionCNPq: 312118/2017-1-
Formato: dc.format947-964-
Idioma: dc.languageen-
Relação: dc.relationJournal of Applied Toxicology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectfertility-
Palavras-chave: dc.subjectmale rat-
Palavras-chave: dc.subjectreproductive toxicity-
Palavras-chave: dc.subjectrosuvastatin-
Palavras-chave: dc.subjectsibutramine-
Título: dc.titleEffects of isolated or combined exposure to sibutramine and rosuvastatin on reproductive parameters of adult male rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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