Variant antigen diversity in Trypanosoma vivax is not driven by recombination

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Autor(es): dc.contributorUniversity of Liverpool-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorInternational Livestock Research Institute-
Autor(es): dc.contributorInternational Research Centre for Livestock Development in the Sub-humid Zone (CIRDES)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorSilva Pereira, Sara-
Autor(es): dc.creatorde Almeida Castilho Neto, Kayo J. G. [UNESP]-
Autor(es): dc.creatorDuffy, Craig W.-
Autor(es): dc.creatorRichards, Peter-
Autor(es): dc.creatorNoyes, Harry-
Autor(es): dc.creatorOgugo, Moses-
Autor(es): dc.creatorRogério André, Marcos [UNESP]-
Autor(es): dc.creatorBengaly, Zakaria-
Autor(es): dc.creatorKemp, Steve-
Autor(es): dc.creatorTeixeira, Marta M. G.-
Autor(es): dc.creatorMachado, Rosangela Z. [UNESP]-
Autor(es): dc.creatorJackson, Andrew P.-
Data de aceite: dc.date.accessioned2022-02-22T00:33:51Z-
Data de disponibilização: dc.date.available2022-02-22T00:33:51Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41467-020-14575-8-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201553-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201553-
Descrição: dc.descriptionAfrican trypanosomes (Trypanosoma) are vector-borne haemoparasites that survive in the vertebrate bloodstream through antigenic variation of their Variant Surface Glycoprotein (VSG). Recombination, or rather segmented gene conversion, is fundamental in Trypanosoma brucei for both VSG gene switching and for generating antigenic diversity during infections. Trypanosoma vivax is a related, livestock pathogen whose VSG lack structures that facilitate gene conversion in T. brucei and mechanisms underlying its antigenic diversity are poorly understood. Here we show that species-wide VSG repertoire is broadly conserved across diverse T. vivax clinical strains and has limited antigenic repertoire. We use variant antigen profiling, coalescent approaches and experimental infections to show that recombination plays little role in diversifying T. vivax VSG sequences. These results have immediate consequences for both the current mechanistic model of antigenic variation in African trypanosomes and species differences in virulence and transmission, requiring reconsideration of the wider epidemiology of animal African trypanosomiasis.-
Descrição: dc.descriptionBiotechnology and Biological Sciences Research Council-
Descrição: dc.descriptionBill and Melinda Gates Foundation-
Descrição: dc.descriptionWellcome Trust-
Descrição: dc.descriptionDepartment of Infection Biology Institute of Infection and Global Health University of Liverpool, 146 Brownlow Hill-
Descrição: dc.descriptionDepartment of Veterinary Pathology Faculty of Agrarian and Veterinary Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Integrative Biology University of Liverpool, Biosciences Building, Crown Street-
Descrição: dc.descriptionLivestock Genetic Programme International Livestock Research Institute, 30709 Naivasha Road-
Descrição: dc.descriptionInternational Research Centre for Livestock Development in the Sub-humid Zone (CIRDES), No. 559, rue 5-31 angle, Avenue du Gouverneur Louveau-
Descrição: dc.descriptionDepartment of Parasitology Institute of Biomedical Sciences University of Sao Paulo, Avenue Professor Lineu Prestes, 1374 Cidade Universitaria-
Descrição: dc.descriptionDepartment of Veterinary Pathology Faculty of Agrarian and Veterinary Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionBiotechnology and Biological Sciences Research Council: BB/M022811/1-
Descrição: dc.descriptionBiotechnology and Biological Sciences Research Council: BB/R021139/1-
Descrição: dc.descriptionBill and Melinda Gates Foundation: GCE Round 11-
Descrição: dc.descriptionWellcome Trust: WT206815/Z/17/Z-
Idioma: dc.languageen-
Relação: dc.relationNature Communications-
???dc.source???: dc.sourceScopus-
Título: dc.titleVariant antigen diversity in Trypanosoma vivax is not driven by recombination-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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