The roles of triiodothyronine and irisin in improving the lipid profile and directing the browning of human adipose subcutaneous cells

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorFederal University of Espírito Santo-
Autor(es): dc.creatorde Oliveira, Miriane [UNESP]-
Autor(es): dc.creatorMathias, Lucas Solla [UNESP]-
Autor(es): dc.creatorRodrigues, Bruna Moretto [UNESP]-
Autor(es): dc.creatorMariani, Bianca Gonçalves [UNESP]-
Autor(es): dc.creatorGraceli, Jones Bernardes-
Autor(es): dc.creatorDe Sibio, Maria Teresa [UNESP]-
Autor(es): dc.creatorCastro Olimpio, Regiane Marques [UNESP]-
Autor(es): dc.creatorFontes Moretto, Fernanda Cristina [UNESP]-
Autor(es): dc.creatorDeprá, Igor Carvalho [UNESP]-
Autor(es): dc.creatorNogueira, Célia Regina [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:33:49Z-
Data de disponibilização: dc.date.available2022-02-22T00:33:49Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-04-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.mce.2020.110744-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201540-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201540-
Descrição: dc.descriptionTriiodothyronine (T3) and irisin (I) can modulate metabolic status, increase heat production, and promote differentiation of white adipose tissue (WAT) into brown adipose tissue (BAT). Herein, human subcutaneous white adipocytes were treated with 10 nM T3 or 20 nM I for 24 h to evaluate intracellular lipid accumulation, triglyceride, and glycerol levels, oxidative stress, DNA damage, and protein levels of uncoupling protein 1 (UCP1), adiponectin, leptin, peroxisome proliferator-activated receptor gamma (PPARγ), and fibronectin type III domain-containing protein 5 (FNDC5). T3 and irisin improved UCP1 production, lipid profile, oxidative stress, and DNA damage. T3 elevated adiponectin and leptin levels with a concomitant decrease in PPARy and FNDC5 levels. However, irisin did not alter adipokine, PPARy, and FNDC5 levels. The results indicate that T3 may be used to increase leptin and adiponectin levels to improve insulin sensitivity, and irisin may be used to prevent obesity or maintain weight due to its impact on the lipid profile without altering adipokine levels.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Internal Clinic Botucatu Medicine School São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Morphology Federal University of Espírito Santo-
Descrição: dc.descriptionDepartment of Internal Clinic Botucatu Medicine School São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2016/03242-3-
Descrição: dc.descriptionCAPES: 409438/2016-
Idioma: dc.languageen-
Relação: dc.relationMolecular and Cellular Endocrinology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectFat-
Palavras-chave: dc.subjectLipid accumulation-
Palavras-chave: dc.subjectOxidative stress-
Palavras-chave: dc.subjectRNA-Seq-
Palavras-chave: dc.subjectThyroid hormone-
Título: dc.titleThe roles of triiodothyronine and irisin in improving the lipid profile and directing the browning of human adipose subcutaneous cells-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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