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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade de São Paulo (USP) | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.creator | de Lima, Eliene Cezario | - |
Autor(es): dc.creator | de Moura, Carolina Foot Gomes | - |
Autor(es): dc.creator | Silva, Marcelo Jose Dias [UNESP] | - |
Autor(es): dc.creator | Vilegas, Wagner [UNESP] | - |
Autor(es): dc.creator | Santamarina, Aline Boveto | - |
Autor(es): dc.creator | Pisani, Luciana Pellegrini | - |
Autor(es): dc.creator | de Oliveira, Flavia | - |
Autor(es): dc.creator | Ribeiro, Daniel Araki | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:33:41Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:33:41Z | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-04-01 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1007/s11356-019-07455-2 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/201489 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/201489 | - |
Descrição: dc.description | The aim of this study was to evaluate the therapeutic properties of Mimosa caesalpiniifolia in liver of rats exposed to cadmium under morphological, oxidative, inflammatory, and mutagenic parameters. A total of 40 Wistar rats (90 days, ~ 250 g) were distributed into eight groups (n = 5) as follows: (i) control; (ii) cadmium: cadmium chloride injection at 1.2 mg/kg; (iii) Mimosa extract: treatment with Mimosa extract at 250 mg/kg; (iv) Mimosa fraction: treatment with Mimosa acetate fraction at 62.5 mg/kg; (v) cadmium and Mimosa extract 62.5: submitted to cadmium chloride at 1.2 mg/kg injection and treatment with Mimosa extract at 62.5 mg/kg; (vi) cadmium and Mimosa extract 125: subjected to cadmium chloride at 1.2 mg/kg injection and treatment with Mimosa extract at 125 mg/kg; (vii) cadmium and Mimosa 250 extract: submitted to cadmium chloride 1.2 mg/kg injection and treatment with Mimosa extract at 250 mg/kg; (viii) cadmium treated with fraction of Mimosa acetate: submitted to cadmium chloride 1.2 mg/kg injection and treatment with acetate fraction of Mimosa extract at 62.5 mg/kg. In the animals intoxicated with cadmium and treated with fraction [62.5], increased expression of SOD-Mn reduced frequency of binucleated hepatocytes, karyolysis, and karyorrhexis, besides the antimutagenic and antioxidant action. The extract [62.5] was cytoprotective, antimutagenic, and reduced karyolysis. The extract [125] was cytoprotective, antioxidant, antifibrotic, anti-inflammatory, and reduced frequency of binucleated hepatocytes, while extract [250] was cytotoxic and mutagenic. In summary, the extract of Mimosa exerts some therapeutic properties in hepatic tissue after Cd intoxication, but only when it is administrated at intermediate doses. Probably, a high content of polyphenols in the EHM [250] and Fr-EtOAc groups exert pro-oxidant activities in the liver particularly when associated with Cd. | - |
Descrição: dc.description | Department of Biosciences Federal University of Sao Paulo UNIFESP, Rua Silva Jardim, 136 | - |
Descrição: dc.description | UNESP São Paulo State University, Coastal Campus | - |
Descrição: dc.description | UNESP São Paulo State University, Coastal Campus | - |
Formato: dc.format | 10981-10989 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Environmental Science and Pollution Research | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | Antioxidants | - |
Palavras-chave: dc.subject | Cadmium | - |
Palavras-chave: dc.subject | Cytotoxicity and micronucleus | - |
Palavras-chave: dc.subject | Mimosa caesalpiniifolia | - |
Título: dc.title | Therapeutical properties of Mimosa caesalpiniifolia in rat liver intoxicated with cadmium | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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