Therapeutical properties of Mimosa caesalpiniifolia in rat liver intoxicated with cadmium

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorde Lima, Eliene Cezario-
Autor(es): dc.creatorde Moura, Carolina Foot Gomes-
Autor(es): dc.creatorSilva, Marcelo Jose Dias [UNESP]-
Autor(es): dc.creatorVilegas, Wagner [UNESP]-
Autor(es): dc.creatorSantamarina, Aline Boveto-
Autor(es): dc.creatorPisani, Luciana Pellegrini-
Autor(es): dc.creatorde Oliveira, Flavia-
Autor(es): dc.creatorRibeiro, Daniel Araki-
Data de aceite: dc.date.accessioned2022-02-22T00:33:41Z-
Data de disponibilização: dc.date.available2022-02-22T00:33:41Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s11356-019-07455-2-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201489-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201489-
Descrição: dc.descriptionThe aim of this study was to evaluate the therapeutic properties of Mimosa caesalpiniifolia in liver of rats exposed to cadmium under morphological, oxidative, inflammatory, and mutagenic parameters. A total of 40 Wistar rats (90 days, ~ 250 g) were distributed into eight groups (n = 5) as follows: (i) control; (ii) cadmium: cadmium chloride injection at 1.2 mg/kg; (iii) Mimosa extract: treatment with Mimosa extract at 250 mg/kg; (iv) Mimosa fraction: treatment with Mimosa acetate fraction at 62.5 mg/kg; (v) cadmium and Mimosa extract 62.5: submitted to cadmium chloride at 1.2 mg/kg injection and treatment with Mimosa extract at 62.5 mg/kg; (vi) cadmium and Mimosa extract 125: subjected to cadmium chloride at 1.2 mg/kg injection and treatment with Mimosa extract at 125 mg/kg; (vii) cadmium and Mimosa 250 extract: submitted to cadmium chloride 1.2 mg/kg injection and treatment with Mimosa extract at 250 mg/kg; (viii) cadmium treated with fraction of Mimosa acetate: submitted to cadmium chloride 1.2 mg/kg injection and treatment with acetate fraction of Mimosa extract at 62.5 mg/kg. In the animals intoxicated with cadmium and treated with fraction [62.5], increased expression of SOD-Mn reduced frequency of binucleated hepatocytes, karyolysis, and karyorrhexis, besides the antimutagenic and antioxidant action. The extract [62.5] was cytoprotective, antimutagenic, and reduced karyolysis. The extract [125] was cytoprotective, antioxidant, antifibrotic, anti-inflammatory, and reduced frequency of binucleated hepatocytes, while extract [250] was cytotoxic and mutagenic. In summary, the extract of Mimosa exerts some therapeutic properties in hepatic tissue after Cd intoxication, but only when it is administrated at intermediate doses. Probably, a high content of polyphenols in the EHM [250] and Fr-EtOAc groups exert pro-oxidant activities in the liver particularly when associated with Cd.-
Descrição: dc.descriptionDepartment of Biosciences Federal University of Sao Paulo UNIFESP, Rua Silva Jardim, 136-
Descrição: dc.descriptionUNESP São Paulo State University, Coastal Campus-
Descrição: dc.descriptionUNESP São Paulo State University, Coastal Campus-
Formato: dc.format10981-10989-
Idioma: dc.languageen-
Relação: dc.relationEnvironmental Science and Pollution Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntioxidants-
Palavras-chave: dc.subjectCadmium-
Palavras-chave: dc.subjectCytotoxicity and micronucleus-
Palavras-chave: dc.subjectMimosa caesalpiniifolia-
Título: dc.titleTherapeutical properties of Mimosa caesalpiniifolia in rat liver intoxicated with cadmium-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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