Modulation of hypercapnic respiratory response by cholinergic transmission in the commissural nucleus of the solitary tract

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorFuruya, Werner I. [UNESP]-
Autor(es): dc.creatorBassi, Mirian [UNESP]-
Autor(es): dc.creatorMenani, José V. [UNESP]-
Autor(es): dc.creatorColombari, Eduardo [UNESP]-
Autor(es): dc.creatorZoccal, Daniel B. [UNESP]-
Autor(es): dc.creatorColombari, Débora S. A. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:33:31Z-
Data de disponibilização: dc.date.available2022-02-22T00:33:31Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00424-019-02341-9-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201433-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201433-
Descrição: dc.descriptionThe nucleus of the solitary tract (NTS) is an important area of the brainstem that receives and integrates afferent cardiorespiratory sensorial information, including those from arterial chemoreceptors and baroreceptors. It was described that acetylcholine (ACh) in the commissural subnucleus of the NTS (cNTS) promotes an increase in the phrenic nerve activity (PNA) and antagonism of nicotinic receptors in the same region reduces the magnitude of tachypneic response to peripheral chemoreceptor stimulation, suggesting a functional role of cholinergic transmission within the cNTS in the chemosensory control of respiratory activity. In the present study, we investigated whether cholinergic receptor antagonism in the cNTS modifies the sympathetic and respiratory reflex responses to hypercapnia. Using an arterially perfused in situ preparation of juvenile male Holtzman rats, we found that the nicotinic antagonist (mecamylamine, 5 mM), but not the muscarinic antagonist (atropine, 5 mM), into the cNTS attenuated the hypercapnia-induced increase of hypoglossal activity. Furthermore, mecamylamine in the cNTS potentiated the generation of late-expiratory (late-E) activity in abdominal nerve induced by hypercapnia. None of the cholinergic antagonists microinjected in the cNTS changed either the sympathetic or the phrenic nerve responses to hypercapnia. Our data provide evidence for the role of cholinergic transmission in the cNTS, acting on nicotinic receptors, modulating the hypoglossal and abdominal responses to hypercapnia.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry UNESP - São Paulo State University-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry UNESP - São Paulo State University-
Descrição: dc.descriptionFAPESP: 2013/17251-6-
Descrição: dc.descriptionFAPESP: 2013/22526-4-
Descrição: dc.descriptionFAPESP: 2015/234677-
Descrição: dc.descriptionCNPq: 304873/2014-4-
Descrição: dc.descriptionCNPq: 310331/2017-0-
Descrição: dc.descriptionCNPq: 408950/2018-8-
Descrição: dc.descriptionCNPq: 425586/2016-2-
Descrição: dc.descriptionCAPES: Finance Code 001-
Formato: dc.format49-60-
Idioma: dc.languageen-
Relação: dc.relationPflugers Archiv European Journal of Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAcetylcholine-
Palavras-chave: dc.subjectBrainstem-
Palavras-chave: dc.subjectChemoreflex-
Palavras-chave: dc.subjectHypercapnia-
Palavras-chave: dc.subjectMuscarinic receptors-
Palavras-chave: dc.subjectNicotinic receptors-
Título: dc.titleModulation of hypercapnic respiratory response by cholinergic transmission in the commissural nucleus of the solitary tract-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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