Gene expression is associated with virulence in murine macrophages infected with Leptospira spp

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorde Araújo, Erivelto Corrêa [UNESP]-
Autor(es): dc.creatorGarcia, Leandro Encarnação [UNESP]-
Autor(es): dc.creatorAraújo, Matheus Janeck [UNESP]-
Autor(es): dc.creatorOliveira-Junior, Itamar Souza-
Autor(es): dc.creatorArnold, Daniel Robert [UNESP]-
Autor(es): dc.creatorLopes, Flavia Lombardi [UNESP]-
Autor(es): dc.creatorMarinho, Márcia [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:33:23Z-
Data de disponibilização: dc.date.available2022-02-22T00:33:23Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0225272-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201380-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201380-
Descrição: dc.descriptionLeptospira genus contains species that affect human health with varying degrees of pathogenicity. In this context, we aimed to evaluate the differences in the modulation of host gene expression by strains of Leptospira varying in virulence. Our data showed a high number of differentially expressed transcripts in murine macrophages following 6h of infection. Leptospira infection modulated a set of genes independently of their degree of virulence. However, pathway analysis indicated that Apoptosis, ATM Signaling, and Cell Cycle: G2/M DNA Damage Checkpoint Regulation were exclusively regulated following infection with the virulent strain. Taken together, results demonstrated that species and virulence play a role during host response to Leptospira spp in murine macrophages, which could contribute to understanding the pathogenesis of leptospirosis.-
Descrição: dc.descriptionDepartment of Production and Animal Health São Paulo State University (Unesp) School of Veterinary Medicine-
Descrição: dc.descriptionDepartment of Surgery Discipline of Anesthesia Pain and Intensive Medicine Federal University of São Paulo-
Descrição: dc.descriptionDepartment of Production and Animal Health São Paulo State University (Unesp) School of Veterinary Medicine-
Idioma: dc.languageen-
Relação: dc.relationPLoS ONE-
???dc.source???: dc.sourceScopus-
Título: dc.titleGene expression is associated with virulence in murine macrophages infected with Leptospira spp-
Tipo de arquivo: dc.typelivro digital-
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