Impact of perinatal bisphenol A and 17β estradiol exposure: Comparing hormone receptor response

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Federal de Sergipe (UFS)-
Autor(es): dc.contributorUniversité Catholique de Louvain (UCL)-
Autor(es): dc.creatorLeonel, Ellen Cristina Rivas [UNESP]-
Autor(es): dc.creatorCampos, Silvana Gisele Pegorin-
Autor(es): dc.creatorGuerra, Luiz Henrique Alves [UNESP]-
Autor(es): dc.creatorBedolo, Carolina Marques [UNESP]-
Autor(es): dc.creatorVilamaior, Patrícia Simone Leite [UNESP]-
Autor(es): dc.creatorCalmon, Marilia Freitas [UNESP]-
Autor(es): dc.creatorRahal, Paula [UNESP]-
Autor(es): dc.creatorAmorim, Christiani Andrade-
Autor(es): dc.creatorTaboga, Sebastião Roberto [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:33:22Z-
Data de disponibilização: dc.date.available2022-02-22T00:33:22Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-01-29-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ecoenv.2019.109918-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201374-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201374-
Descrição: dc.descriptionHormonal regulation controls mammary gland (MG) development. Therefore some hormone-related factors can disrupt the early phases of MGs development, making the gland more susceptible to long term modifications in its response to circulating hormones. Endocrine disruptors, such as bisphenol A (BPA), are able to cause alterations in hormone receptor expression, leading to changes in the cell proliferation index, which may expose the tissue to neoplastic alterations. Thus, we evaluated the variations in hormone receptor expression in the MG of 6-month old Mongolian gerbils exposed to BPA and 17β estradiol during the perinatal period. Receptors for estrogen alpha (ERα), beta (ERβ), progesterone (PGR), prolactin (PRL-R), and co-localization of connexin 43 (Cx43) and ERα in gerbils were analyzed, and serum concentrations of estradiol and progesterone were assessed. No alterations in body, liver, and ovary-uterus complex weights were observed. However, there was an increase in epithelial ERα expression in the 17β estradiol (E2) group and in PGR in the BPA group. Although immunohistochemistry did not show alterations in ERβ expression, western blotting revealed a decrease in this protein in the BPA group. PRL-R was more present in epithelial cells in the vehicle control (VC), E2, and BPA groups in comparison to the intact control group. Cx43 was more frequent in E2 and BPA groups, suggesting a protective response from the gland against possible malignancy. Serum concentration of estradiol reduced in VC, E2, and BPA groups, confirming that alterations also impacts steroid levels. Consequently, perinatal exposure to BPA and the reference endogenous estrogen, 17β estradiol, are able to increase the tendency of endocrine disruption in MG in a long term manner, since repercussions are observed even 6 months after exposure.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Biology Institute of Biosciences Humanities and Exact Sciences São Paulo State University (UNESP), Rua Cristóvão Colombo 2265, Jardim Nazareth-
Descrição: dc.descriptionFederal University of São João del Rei (UFSJ) Campus Centro Oeste Dona Lindu, Avenida Sebastião Gonçalves Coelho, 400, Bairro Chanadour-
Descrição: dc.descriptionLaboratory of Gynecology Institute of Experimental and Clinique Research Université Catholique de Louvain (UCL), Avenue Mounier 52, Bte B1.52.02-
Descrição: dc.descriptionDepartment of Biology Institute of Biosciences Humanities and Exact Sciences São Paulo State University (UNESP), Rua Cristóvão Colombo 2265, Jardim Nazareth-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2015/01548–5-
Descrição: dc.descriptionFAPESP: 2016/22947–8-
Descrição: dc.descriptionCNPq: 305840/2015–0-
Idioma: dc.languageen-
Relação: dc.relationEcotoxicology and Environmental Safety-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEstrogen-
Palavras-chave: dc.subjectEstrogen receptor-
Palavras-chave: dc.subjectMammary gland-
Palavras-chave: dc.subjectMongolian gerbil-
Palavras-chave: dc.subjectProgesterone receptor-
Palavras-chave: dc.subjectXenoestrogen-
Título: dc.titleImpact of perinatal bisphenol A and 17β estradiol exposure: Comparing hormone receptor response-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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