Effects of surface pre-reacted glass-ionomer (S-PRG) eluate on Candida spp.: antifungal activity, anti-biofilm properties, and protective effects on Galleria mellonella against C. albicans infection

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorSHOFU Inc.-
Autor(es): dc.creatorRossoni, Rodnei Dennis [UNESP]-
Autor(es): dc.creatorde Barros, Patrícia Pimentel [UNESP]-
Autor(es): dc.creatorLopes, Lucas Alexandre das Chagas [UNESP]-
Autor(es): dc.creatorRibeiro, Felipe Camargo [UNESP]-
Autor(es): dc.creatorNakatsuka, Toshiyuki-
Autor(es): dc.creatorKasaba, Hideto-
Autor(es): dc.creatorJunqueira, Juliana Campos [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:33:18Z-
Data de disponibilização: dc.date.available2022-02-22T00:33:18Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-10-20-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/08927014.2019.1686485-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201343-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201343-
Descrição: dc.descriptionSurface pre-reacted glass-ionomer (S-PRG) is a bioactive filler produced by PRG technology, which is applied to various dental materials. The inhibitory effects of S-PRG eluate against Candida, the most common fungal oral pathogen, were investigated. Minimum inhibitory concentrations (MIC) and anti-biofilm activities were tested against Candida albicans, Candida glabrata, Candida krusei, and Candida tropicalis. For the in vivo study, Galleria mellonella was used as a model to evaluate the effects of S-PRG on toxicity, hemocyte counts and candidiasis. The MIC of S-PRG ranged from 5 to 40% (v/v). S-PRG eluate exhibited anti-biofilm activity for all the Candida species tested. Furthermore, injection of S-PRG eluate into G. mellonella was not toxic to the larvae and protected G. mellonella against experimental candidiasis. In addition, S-PRG eluate inhibited biofilm formation by C. albicans, C. glabrata, C. krusei, and C. tropicalis and exerted protective effects on G. mellonella against experimental candidiasis in vivo.-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology UNESP - Univ Estadual Paulista-
Descrição: dc.descriptionDepartment of Research SHOFU Inc.-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology UNESP - Univ Estadual Paulista-
Formato: dc.format997-1006-
Idioma: dc.languageen-
Relação: dc.relationBiofouling-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbiofilms-
Palavras-chave: dc.subjectCandida spp-
Palavras-chave: dc.subjectGalleria mellonella-
Palavras-chave: dc.subjectS-PRG filler-
Título: dc.titleEffects of surface pre-reacted glass-ionomer (S-PRG) eluate on Candida spp.: antifungal activity, anti-biofilm properties, and protective effects on Galleria mellonella against C. albicans infection-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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