Synthesis and anti-inflammatory intestinal activity of new glucocorticoid derivatives

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorMachado, Marcella Gabrielle Mendes [UNESP]-
Autor(es): dc.creatorScarim, Cauê Benito [UNESP]-
Autor(es): dc.creatorde Andrade, Cleverton Roberto [UNESP]-
Autor(es): dc.creatordos Santos, Jean Leandro [UNESP]-
Autor(es): dc.creatorChin, Chung Man [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:33:17Z-
Data de disponibilização: dc.date.available2022-02-22T00:33:17Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00044-019-02474-7-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201339-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201339-
Descrição: dc.descriptionGlucocorticoids (GCs) are used worldwide in the treatment of chronic inflammatory diseases. This study describes the synthesis of new glucocorticoid derivatives and evaluates anti-inflammatory activity in rat models with ulcerative colitis (UC). Six compounds (5a–f) were synthetized using the molecular hybridization strategy with yields of 40–80%. The compounds 5e and 5f showed a total regression of ulceration in 83.3% and 75% of treated animals, respectively. Moreover, 5e improved several clinical signs, such as weight gain and survival rates. The compounds 5a and 5c showed total regression of ulceration in 33.3% of the rats. This is higher than prednisolone. Glucocorticoid derivatives showed potential anti-inflammatory intestinal activity with regression of ulceration in colitis.-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP), Rodovia Araraquara-Jaú km-1 s/n, campus ville-
Descrição: dc.descriptionSchool of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP), Rodovia Araraquara-Jaú km-1 s/n, campus ville-
Descrição: dc.descriptionSchool of Dentistry São Paulo State University (UNESP)-
Formato: dc.format206-216-
Idioma: dc.languageen-
Relação: dc.relationMedicinal Chemistry Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBudesonide-
Palavras-chave: dc.subjectColitis-
Palavras-chave: dc.subjectMolecular hybridization-
Palavras-chave: dc.subjectPhthalimide-
Palavras-chave: dc.subjectPrednisolone-
Título: dc.titleSynthesis and anti-inflammatory intestinal activity of new glucocorticoid derivatives-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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