Anti-inflammatory and anti-resorptive efficacy of adrenergic blockers on late replanted rat incisors

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorThe University of Birmingham School of Dentistry-
Autor(es): dc.creatorMatos, Felipe de Souza [UNESP]-
Autor(es): dc.creatordo Prado, Renata Falchete [UNESP]-
Autor(es): dc.creatorKhoury, Rayana Duarte [UNESP]-
Autor(es): dc.creatorde Oliveira, Luciane Dias [UNESP]-
Autor(es): dc.creatorValera, Marcia Carneiro [UNESP]-
Autor(es): dc.creatorTomson, Phillip Leo-
Autor(es): dc.creatorCarvalho, Cláudio Antonio Talge [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:33:14Z-
Data de disponibilização: dc.date.available2022-02-22T00:33:14Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/edt.12523-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201328-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201328-
Descrição: dc.descriptionBackground/Aim: In addition to their anti-inflammatory and anti-osteoclastogenesis properties, adrenergic blockers may also have promising anti-resorptive effects that can prevent root resorption when teeth are replanted because of avulsion. The aim of this study was to investigate the effects of phentolamine (Ph) and propranolol (Pr) in gels on the repair process of late replanted rat incisors. A further aim was to evaluate the biocompatibility of both drugs to human periodontal ligament fibroblasts (HPDLFs). Materials and methods: Forty-eight maxillary right incisors were extracted from male Wistar rats, stored in paper napkins for 60 minutes, and randomly allocated to one of eight groups (n = 6). The root canal, root surface, and alveolus were treated with 0.75 µg/mL Ph gel (Ph0.75), 10 µg/mL Ph gel (Ph10), 100 µg/mL Ph gel (Ph100), 2.5 µg/mL Pr gel (Pr2.5), 10 µg/mL Pr gel (Pr10), 100 µg/mL Pr gel (Pr100), or sodium carboxymethylcellulose gel (CMC) before replantation. In the control group (CH), only the root canal was treated with calcium hydroxide paste. Thirty days following surgery, the animals were euthanized, and the right hemimaxilla was removed to perform micro-CT and histomorphometric analysis to determine osteoclastic activity. Ethanolic solutions of Ph10 and Pr10 were selected based on the in vivo study, and the viability of HPDLFs stimulated with lipopolysaccharide was determined by MTT assays. Results: The micro-CT and histomorphometric analysis revealed no significant differences among the treatments (P >.05). The presence of active osteoclasts was significantly decreased in the Ph10 and Pr10 groups (P <.05). Ph10 and Pr10 produced statistically similar cell survival rates compared to the control group (P >.05). Conclusions: Ph10 and Pr10 significantly decreased osteoclastogenesis in delayed replanted rat teeth and were not cytotoxic toward HPDLFs.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Restorative Dentistry Endodontic Division Institute of Science and Technology São Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Oral Biology Institute of Clinical Sciences The University of Birmingham School of Dentistry-
Descrição: dc.descriptionDepartment of Restorative Dentistry Endodontic Division Institute of Science and Technology São Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (Unesp)-
Descrição: dc.descriptionCNPq: 431807/2016-7-
Formato: dc.format253-263-
Idioma: dc.languageen-
Relação: dc.relationDental Traumatology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectadrenergic blockers-
Palavras-chave: dc.subjectphentolamine-
Palavras-chave: dc.subjectpropranolol-
Palavras-chave: dc.subjectroot resorption-
Palavras-chave: dc.subjecttooth avulsion-
Palavras-chave: dc.subjecttooth replantation-
Título: dc.titleAnti-inflammatory and anti-resorptive efficacy of adrenergic blockers on late replanted rat incisors-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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