Simultaneous degradation of the anticancer drugs 5-fluorouracil and cyclophosphamide using a heterogeneous photo-Fenton process based on copper-containing magnetites (Fe3-xCuxO4)

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorEmídio, Elissandro Soares [UNESP]-
Autor(es): dc.creatorHammer, Peter [UNESP]-
Autor(es): dc.creatorNogueira, Raquel F. Pupo [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:32:54Z-
Data de disponibilização: dc.date.available2022-02-22T00:32:54Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.chemosphere.2019.124990-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201207-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201207-
Descrição: dc.descriptionThe effect of substitution of iron by copper in the magnetite lattice was investigated in terms of the catalytic activity in the heterogeneous photo-Fenton process. The physicochemical properties of the Fe3-xCuxO4 nanoparticles were characterized by X-ray diffraction (XRD), X-ray fluorescence (WD-XRF), specific surface area measurements, field emission scanning electron microscopy (FEG-SEM), and X-ray photoelectron spectroscopy (XPS). Copper-modified magnetite showed higher catalytic activity for H2O2 conversion to HO• (estimated using 7-hydroxycoumarin), compared to pristine magnetite (Fe3O4). Consequently, improved degradation of the anticancer drugs 5-fluorouracil (5-FU) and cyclophosphamide (CP) was observed, with high efficiencies achieved using Fe2.75Cu0.25O4 (0.125 g L−1) and 15 mmol L−1 H2O2, at pH 6.5, which resulted in complete degradation of 7.7 μmol L−1 5-FU and CP after 150 min. Low leaching of Cu and Fe demonstrated the stability of the catalyst in the Fenton process, with high catalytic activity (>90%) maintained after use in 4 cycles. The addition of radical scavengers such as methanol, tert-butanol and iodide ions indicated that surface-bonded hydroxyl radicals played a major role in the degradation of 5-FU and CP in the Fe3-xCuxO4/H2O2 system. The substitution of octahedral Fe(II) sites of the magnetite lattice by Cu(II) and the partial oxidation of Cu(I) to Cu(II) and Fe(II) to Fe(III) on the catalyst surface after the Fenton reaction were confirmed by analysis of the XPS spectra.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Chemistry-
Descrição: dc.descriptionUNESP National Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM) Institute of Chemistry, P.O. Box 355-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Chemistry-
Descrição: dc.descriptionUNESP National Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM) Institute of Chemistry, P.O. Box 355-
Descrição: dc.descriptionFAPESP: #2014/50945-4-
Descrição: dc.descriptionFAPESP: #2016/11373-0-
Descrição: dc.descriptionCNPq: #465571/2014-0-
Descrição: dc.descriptionCAPES: #88887136426/2017/00-
Idioma: dc.languageen-
Relação: dc.relationChemosphere-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCu modified nanoparticles-
Palavras-chave: dc.subjectCytostatic drugs-
Palavras-chave: dc.subjectFenton reaction-
Palavras-chave: dc.subjectHydroxyl radicals-
Palavras-chave: dc.subjectMagnetite-
Título: dc.titleSimultaneous degradation of the anticancer drugs 5-fluorouracil and cyclophosphamide using a heterogeneous photo-Fenton process based on copper-containing magnetites (Fe3-xCuxO4)-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.