Oral Colonization by Candida Species in Patients with Multiple Sclerosis

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorIrmandade da Santa Casa de Misericórdia de São Paulo-
Autor(es): dc.contributorFaculty of Medical Sciences of Santa Casa de São Paulo-
Autor(es): dc.creatorda Cunha, Eliana Tomomi Shimabukuro [UNESP]-
Autor(es): dc.creatorFigueiredo-Godoi, Lívia Mara Alves [UNESP]-
Autor(es): dc.creatorSantos, Diogo Haddad-
Autor(es): dc.creatorCarneiro, Rafael Paterno Castello Dias-
Autor(es): dc.creatordo Olival, Guilherme Sciascia-
Autor(es): dc.creatorde Barros, Patrícia Pimentel [UNESP]-
Autor(es): dc.creatorNarimatsu, Keila-
Autor(es): dc.creatorTilbery, Charles Peter-
Autor(es): dc.creatorJunqueira, Juliana Campos [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:32:46Z-
Data de disponibilização: dc.date.available2022-02-22T00:32:46Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s11046-020-00486-1-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201159-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201159-
Descrição: dc.descriptionIntroduction: Multiple sclerosis (MS) is a chronic inflammatory demyelinating autoimmune disease that affects the central nervous system. Since immune system plays a key role in this disease, patients with MS can present higher risk of infections. Purpose: This study aimed to investigate the prevalence of Candida spp. in the oral cavity of MS patients in relation to a control group Methods: In total, 100 individuals were selected: 55 diagnosed with MS and 45 healthy individuals (control group). Saliva samples were collected and seeded in culture media selecting for Candida. Following an incubation period of 48 h, colony-forming units (CFU mL−1) were counted and colonies were isolated for Candida species identification by multiplex PCR. The results were analysed by chi-squared and Mann–Whitney U statistical tests considering a significance level of 5%. Results: Candida spp. were confirmed in the oral cavity of 50.09% patients in the MS group and 35.55% individuals in the control group. In individuals positive for the growth of Candida spp., the median values of Candida colonies were 220 CFU mL−1 for the MS group and 120 CFU mL−1 for the control group. However, no statistically significant differences were observed between groups for both prevalence and CFU mL−1 count. Of the Candida species identified, 73.91% were C. albicans, 21.73% C. glabrata, 2.17% C. tropicalis, and 2.17% C. krusei. Conclusions: The colonization of Candida spp. in the oral cavity of individuals with multiple sclerosis was higher than in the control group; however these findings were not proven to be statistically significant.-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP), Francisco José Longo 777, São Dimas-
Descrição: dc.descriptionIrmandade da Santa Casa de Misericórdia de São Paulo-
Descrição: dc.descriptionDepartment of Neurology Faculty of Medical Sciences of Santa Casa de São Paulo-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP), Francisco José Longo 777, São Dimas-
Idioma: dc.languageen-
Relação: dc.relationMycopathologia-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAutoimmune disease-
Palavras-chave: dc.subjectCandida-
Palavras-chave: dc.subjectCandida albicans-
Palavras-chave: dc.subjectDemyelinating disease-
Palavras-chave: dc.subjectMicrobiota-
Palavras-chave: dc.subjectMultiple sclerosis-
Título: dc.titleOral Colonization by Candida Species in Patients with Multiple Sclerosis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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