New Silver(I) Coordination Compound Loaded into Polymeric Nanoparticles as a Strategy to Improve in Vitro Anti- Helicobacter pylori Activity

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Araraquara-
Autor(es): dc.creatorAlmeida Furquim De Camargo, Bruna [UNESP]-
Autor(es): dc.creatorSoares Silva, Débora Eduarda [UNESP]-
Autor(es): dc.creatorNoronha Da Silva, Anderson [UNESP]-
Autor(es): dc.creatorCampos, Débora Leite [UNESP]-
Autor(es): dc.creatorMacHado Ribeiro, Tamara Renata [UNESP]-
Autor(es): dc.creatorMieli, Maria Júlia-
Autor(es): dc.creatorBorges Teixeira Zanatta, Melina [UNESP]-
Autor(es): dc.creatorBento Da Silva, Patrícia [UNESP]-
Autor(es): dc.creatorPavan, Fernando Rogerio [UNESP]-
Autor(es): dc.creatorGallina Moreira, Cristiano [UNESP]-
Autor(es): dc.creatorResende, Flávia Aparecida-
Autor(es): dc.creatorMenegário, Amauri Antônio [UNESP]-
Autor(es): dc.creatorChorilli, Marlus [UNESP]-
Autor(es): dc.creatorVieira De Godoy Netto, Adelino [UNESP]-
Autor(es): dc.creatorBauab, Taís Maria [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:32:43Z-
Data de disponibilização: dc.date.available2022-02-22T00:32:43Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-07-06-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1021/acs.molpharmaceut.9b01264-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201142-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201142-
Descrição: dc.descriptionHelicobacter pylori inhabits the gastric epithelium and can promote the development of gastric disorders, such as peptic ulcers, acute and chronic gastritis, mucosal lymphoid tissue (MALT), and gastric adenocarcinomas. To use nanotechnology as a tool to increase the antibacterial activity of silver I [Ag(I)] compounds, this study suggests a new strategy for H. pylori infections, which have hitherto been difficult to control. [Ag (PhTSC·HCl)2] (NO3)·H2O (compound 1) was synthesized, characterized, and loaded into polymeric nanoparticles (PN1). PN1 had been developed by nanoprecipitation with poly(ϵ-caprolactone) polymer and poloxamer 407 surfactant. System characterization assays showed that the PNs had adequate particle sizes and ζ-potentials. Transmission electron microscopy confirmed the formation of polymeric nanoparticles (PNs). Compound 1 had a minimum inhibitory concentration for H. pylori of 3.90 μg/mL, which was potentiated to 0.781 μg/mL after loading. The minimum bactericidal concentration of 7.81 μg/mL was potentiated 5-fold to 1.56 μg/mL in PN. Compound 1 loaded in PN1 displayed better activity for H. pylori biofilm formation and mature biofilm. PN1 reduced the toxicity of compound 1 to MRC-5 cells. Loading compound 1 into PN1 inhibited the mutagenicity of the free compound. In vivo, the system allowed survival of Galleria mellonella larvae at a concentration of 200 μg/mL. This is the first demonstration of the antibacterial activity of a silver complex enclosed in polymeric nanoparticles against H. pylori.-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Biological Sciences and Health University of Araraquara-
Descrição: dc.descriptionEnvironmental Studies Center São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionEnvironmental Studies Center São Paulo State University (UNESP)-
Formato: dc.format2287-2298-
Idioma: dc.languageen-
Relação: dc.relationMolecular Pharmaceutics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbiofilm-
Palavras-chave: dc.subjectHelicobacter pylori-
Palavras-chave: dc.subjectpolymeric nanoparticle-
Palavras-chave: dc.subjectsilver-
Título: dc.titleNew Silver(I) Coordination Compound Loaded into Polymeric Nanoparticles as a Strategy to Improve in Vitro Anti- Helicobacter pylori Activity-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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