Atenção: Todas as denúncias são sigilosas e sua identidade será preservada.
Os campos nome e e-mail são de preenchimento opcional
Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | University of Texas at Dallas | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Universidade de São Paulo (USP) | - |
Autor(es): dc.creator | Wheelis, Sutton E. | - |
Autor(es): dc.creator | Biguetti, Claudia C. [UNESP] | - |
Autor(es): dc.creator | Natarajan, Shruti | - |
Autor(es): dc.creator | Guida, Lidia | - |
Autor(es): dc.creator | Hedden, Brian | - |
Autor(es): dc.creator | Garlet, Gustavo P. | - |
Autor(es): dc.creator | Rodrigues, Danieli C. | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:32:36Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:32:36Z | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-02-09 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1021/acsbiomaterials.9b01884 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/201107 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/201107 | - |
Descrição: dc.description | Dicationic imidazolum-based ionic liquids with amino acid anions (IonL) have been proposed as a multifunctional coating for titanium dental implants, as their properties have been shown to address multiple early complicating factors while maintaining host cell compatibility. This study aims to evaluate effects of this coating on host response in the absence of complicating oral factors during the early healing period using a subcutaneous implantation model in the rat. IonLs with the best cytocompatibility and antimicrobial properties (IonL-Phe, IonL-Met) were chosen as coatings. Three different doses were applied to cpTi disks and subcutaneously implanted into 36 male Lewis rats. Rats received two implants: one coated implant on one side and an uncoated implant on the contralateral sides (n = 3 per formulation, per dose). Peri-implant tissue was evaluated 2 and 14 days after implantation with H&E staining and IHC markers associated with macrophage polarization as well as molecular analysis (qPCR) for inflammatory and healing markers. H&E stains revealed the presence of the coating, blood clots, and inflammatory infiltrate at 2 days around all implants. At 14 days, inflammation had receded with more developed connective tissue with fibroblasts, blood vessels in certain doses of coated and uncoated samples with no foreign body giant cells. This study demonstrated that IonL at the appropriate concentration does not significantly interfere with healing and Ti foreign body response. Results regarding optimal dose and formulation from this study will be applied in future studies using an oral osseointegration model. | - |
Descrição: dc.description | Deparment of Bioengineering University of Texas at Dallas | - |
Descrição: dc.description | Department of Basic Sciences São Paulo State University (UNESP) School of Dentistry | - |
Descrição: dc.description | Department of Biological Sciences University of Texas at Dallas | - |
Descrição: dc.description | Bauru School of Dentistry Department of Biological Sciences University of São Paulo | - |
Descrição: dc.description | Department of Basic Sciences São Paulo State University (UNESP) School of Dentistry | - |
Formato: dc.format | 984-994 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | ACS Biomaterials Science and Engineering | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | early healing | - |
Palavras-chave: dc.subject | histology | - |
Palavras-chave: dc.subject | ionic liquids | - |
Palavras-chave: dc.subject | multifunctional coatings | - |
Palavras-chave: dc.subject | subcutaneous implant | - |
Palavras-chave: dc.subject | titanium | - |
Título: dc.title | Investigation of the Early Healing Response to Dicationic Imidazolium-Based Ionic Liquids: A Biocompatible Coating for Titanium Implants | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
O Portal eduCAPES é oferecido ao usuário, condicionado à aceitação dos termos, condições e avisos contidos aqui e sem modificações. A CAPES poderá modificar o conteúdo ou formato deste site ou acabar com a sua operação ou suas ferramentas a seu critério único e sem aviso prévio. Ao acessar este portal, você, usuário pessoa física ou jurídica, se declara compreender e aceitar as condições aqui estabelecidas, da seguinte forma: