MicroRNA-126 upregulation, induced by training, plays a role in controlling microcirculation in dexamethasone treated rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorHerrera, Naiara A. [UNESP]-
Autor(es): dc.creatorDuchatsch, Francine [UNESP]-
Autor(es): dc.creatorTardelli, Lidieli P. [UNESP]-
Autor(es): dc.creatorDionísio, Thiago J.-
Autor(es): dc.creatorShinohara, Andre L.-
Autor(es): dc.creatorSantos, Carlos F.-
Autor(es): dc.creatorAmaral, Sandra Lia [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:32:36Z-
Data de disponibilização: dc.date.available2022-02-22T00:32:36Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-04-05-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.mce.2020.110732-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201101-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201101-
Descrição: dc.descriptionMicrocirculation maintenance is associated with microRNAs. Nevertheless, the role of microRNAs induced by training in preventing dexamethasone (DEX)-induced microvascular rarefaction remains unknown. The study aim was to investigate if training-induced microRNAs are able to improve microcirculation proteins and prevent DEX-induced microvascular rarefaction. Rats underwent training for 8 weeks and then were treated with DEX (50 μg/kg per day, s.c.) for 14 days. Arterial pressure was measured and tibialis anterior (TA) muscle was collected for analyses. DEX induced hypertension concomitantly with capillary density loss (CD, −23.9%) and decrease of VEGF (−43.0%), p-AKT/AKT (−39.6%) and Bcl-2 (−23.0%) and an increase in caspase-3-cleaved protein level (+34.0%) in TA muscle. Training upregulated microRNA-126 expression (+13.1%), prevented VEGF (+61.4%), p-AKT/AKT (+37.7%), Bcl-2 (+7.7%) decrease and caspase-3-cleaved (−23.1%) increase associated with CD (+54.7%) reduction and hypertension prevention. MiRNA-126 upregulation, induced by training, plays a role in controlling microcirculation, which may be a potential target against DEX-induced microvascular rarefaction.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionJoint Graduate Program in Physiological Sciences PIPGCF UFSCar/UNESP, Rodovia Washington Luiz, km 235 Monjolinho 676-
Descrição: dc.descriptionDepartment of Biological Sciences Bauru School of Dentistry University of São Paulo, Alameda Octávio Pinheiro Brisolla 9-75-
Descrição: dc.descriptionDepartment of Physical Education - São Paulo State University (UNESP) School of Sciences, Av. Eng. Luiz Edmundo Carrijo Coube, 14-01, Vargem Limpa-
Descrição: dc.descriptionJoint Graduate Program in Physiological Sciences PIPGCF UFSCar/UNESP, Rodovia Washington Luiz, km 235 Monjolinho 676-
Descrição: dc.descriptionDepartment of Physical Education - São Paulo State University (UNESP) School of Sciences, Av. Eng. Luiz Edmundo Carrijo Coube, 14-01, Vargem Limpa-
Descrição: dc.descriptionFAPESP: 2015/03965-2-
Descrição: dc.descriptionFAPESP: 2016/12532-5-
Descrição: dc.descriptionFAPESP: 2017/00509-1-
Descrição: dc.descriptionFAPESP: 2017/14405-3-
Descrição: dc.descriptionFAPESP: 2018/06998-7-
Descrição: dc.descriptionCAPES: 88882.426901/2019-01-
Descrição: dc.descriptionCAPES: 88882.426908/2019-01-
Idioma: dc.languageen-
Relação: dc.relationMolecular and Cellular Endocrinology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectArterial pressure-
Palavras-chave: dc.subjectGlucocorticoids-
Palavras-chave: dc.subjectMicrocirculation-
Palavras-chave: dc.subjectPhysical training-
Palavras-chave: dc.subjectSkeletal muscle-
Título: dc.titleMicroRNA-126 upregulation, induced by training, plays a role in controlling microcirculation in dexamethasone treated rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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