Training counteracts DEX-induced microvascular rarefaction by improving the balance between apoptotic and angiogenic proteins

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorJesus, Isley [UNESP]-
Autor(es): dc.creatorHerrera, Naiara A. [UNESP]-
Autor(es): dc.creatorAndreo, Jesus C.-
Autor(es): dc.creatorSantos, Carlos F.-
Autor(es): dc.creatorAmaral, Sandra L. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:32:35Z-
Data de disponibilização: dc.date.available2022-02-22T00:32:35Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.steroids.2019.108573-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201097-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201097-
Descrição: dc.descriptionThis work investigated the mechanisms induced by exercise training that may contribute to attenuate dexamethasone (DEX)-induced microvascular rarefaction and hypertension. Wistar rats underwent training protocol or were kept sedentary for 8 weeks. Dexamethasone was administered during the following 14-days and hemodynamic parameters were recorded at the end. Capillary density (CD) and capillary-to-fiber ratio (C:F ratio) were obtained in soleus muscle (SOL). Also, vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor-2 (VEGFR-2), endothelial nitric oxide synthase (eNOS), B-cell lymphoma 2 (Bcl-2), Bcl-2-like protein 4 (Bax), p-BAX and caspase-3 cleaved protein levels were analyzed. DEX treatment significantly increased blood pressure (+14%), which was associated with reduced C:F ratio (−41.0%) and CD (−43.1%). Reduction of vessel density was associated with decreased VEGF (−15.6%), VEGFR-2 (−14.6%), Bcl-2 (−18.4%), Bcl-2/Bax ratio (−29.0%) and p-Bax/Bax (−25.4%), and also with increased caspase-3 cleaved protein level (25%). Training, on the other hand, prevented microvessels loss by mitigating all proteins changes induced by DEX. In addition, angiogenic and apoptotic proteins were significantly correlated with CD, which, in turn, was associated with blood pressure. Therefore, we may point out that exercise training is a good strategy to attenuate DEX-induced microvascular rarefaction in soleus muscle and this response involves a better balance between apoptotic and angiogenic proteins, which may contribute for the attenuation of hypertension.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Physical Education – São Paulo State University (UNESP) Science Faculty, Av. Eng. Luiz Edmundo Carrijo Coube, 14-01 – Vargem Limpa-
Descrição: dc.descriptionJoint Graduate Program in Physiological Sciences PIPGCF UFSCar/UNESP, Rodovia Washington Luiz, km 235 Monjolinho, 676-
Descrição: dc.descriptionDepartment of Biological Sciences Bauru School of Dentistry University of São Paulo, Alameda Octávio Pinheiro Brisolla, 9-75-
Descrição: dc.descriptionDepartment of Physical Education – São Paulo State University (UNESP) Science Faculty, Av. Eng. Luiz Edmundo Carrijo Coube, 14-01 – Vargem Limpa-
Descrição: dc.descriptionJoint Graduate Program in Physiological Sciences PIPGCF UFSCar/UNESP, Rodovia Washington Luiz, km 235 Monjolinho, 676-
Idioma: dc.languageen-
Relação: dc.relationSteroids-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAngiogenesis-
Palavras-chave: dc.subjectApoptosis-
Palavras-chave: dc.subjectBlood pressure-
Palavras-chave: dc.subjectExercise training-
Palavras-chave: dc.subjectSkeletal muscle-
Palavras-chave: dc.subjectSteroid hormone-
Título: dc.titleTraining counteracts DEX-induced microvascular rarefaction by improving the balance between apoptotic and angiogenic proteins-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.