EPILAT-IRA study: A contribution to the understanding of the epidemiology of acute kidney injury in Latin America

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidad de la República-
Autor(es): dc.contributorUniversidad Mayor de San Simon School of Medicine-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorHospital Italiano-
Autor(es): dc.contributorUniversity of Rio de Janeiro-
Autor(es): dc.contributorHospital Provincial-
Autor(es): dc.contributorCentro Universitario de Ciencias de la Salud-
Autor(es): dc.contributorUniversidade Nove de Julho-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorPetrópolis-
Autor(es): dc.contributorSanatorio Casa de Galicia-
Autor(es): dc.contributorServicio de Nefrología-
Autor(es): dc.contributorIMSS-
Autor(es): dc.creatorLombardi, Raúl-
Autor(es): dc.creatorFerreiro, Alejandro-
Autor(es): dc.creatorGranado, Rolando Claure-Del-
Autor(es): dc.creatorBurdmann, Emmanuel A.-
Autor(es): dc.creatorRosa-Diez, Guillermo-
Autor(es): dc.creatorYu, Luis-
Autor(es): dc.creatorYounes-Ibrahim, Mauricio-
Autor(es): dc.creatorCarlino, Cristina-
Autor(es): dc.creatorChávez-Iñiguez, Jonathan S.-
Autor(es): dc.creatorPereira, Mariana B.-
Autor(es): dc.creatorVarela, Carlos F.-
Autor(es): dc.creatorZamoner, Welder [UNESP]-
Autor(es): dc.creatorJaniques, Diego-
Autor(es): dc.creatorLecueder, Soledad-
Autor(es): dc.creatorCerrón-Millán, Víctor-
Autor(es): dc.creatorCueto-Manzano, Alfonso-
Data de aceite: dc.date.accessioned2022-02-22T00:32:33Z-
Data de disponibilização: dc.date.available2022-02-22T00:32:33Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0224655-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201084-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201084-
Descrição: dc.descriptionIntroduction Epidemiology of acute kidney injury (AKI) is highly dependent on patient characteristics, context and geography. Considering the limited information in Latin America and the Caribbean, we performed a study with the aim to contribute to improve its better understanding. Methods Observational, prospective, longitudinal, multinational cohort study addressed to determine risk factors, clinical profile, process of care and outcomes of AKI in the region. Patients meeting KDIGO AKI definition were included over a 9-month period and designated community or hospital-acquired. De-identified clinical and lab data were entered in a specifically designed on-line platform. Co-variables potentially linked to AKI onset, in-hospital and 90-days mortality, were recorded and correlated using a multiple logistic regression model. Results Fifty-seven physicians from 15 countries provided data on 905 patients, most with acceptable basic needs coverage. Median age 64 (50–74) yrs; most of them were male (61%) and mestizos (42%). Comorbidities were present in 77%. AKI was community-acquired in 62%. Dehydration, shock and nephrotoxic drugs were the commonest causes. During their process of care, 77% of patients were assessed by nephrologists. Kidney replacement therapy (KRT) was performed in 29% of cases. In-hospital mortality was 26.5% and independently associated to older age, chronic liver disease, hypotension, shock, cardiac disturbances, hospital-acquired sepsis, KRT and mechanical ventilation. At 90-days follow up partial or complete renal recovery was 81% and mortality 24%. Conclusions AKI was mainly community-acquired, in patients with comorbidities and linked to fluid loss and nephrotoxic drugs. Mortality was high and long-term follow up poor. Notwithstanding, the study shows partially the situation in the participant countries rather than the actual epidemiology of AKI in Latin America and Caribbean, a pending and needed task.-
Descrição: dc.descriptionDept. of Nephrology School of Medicine Universidad de la República-
Descrição: dc.descriptionDivision of Nephrology Hospital Obrero #2 - C.N.S. Universidad Mayor de San Simon School of Medicine-
Descrição: dc.descriptionLIM 12 Division of Nephrology University of Sao Paulo Medical School-
Descrição: dc.descriptionDept. of Nehrology Hospital Italiano-
Descrição: dc.descriptionDept. of Internal Medicine University of Rio de Janeiro-
Descrição: dc.descriptionHospital Provincial-
Descrição: dc.descriptionHospital Civil de Guadalajara Centro Universitario de Ciencias de la Salud-
Descrição: dc.descriptionNephrology Division Hospital do Servidor Público Estadual Universidade Nove de Julho-
Descrição: dc.descriptionBotucatu School of Medicine São Paulo State University-UNESP-
Descrição: dc.descriptionClinica Renalle Pontifícia Universidade Católica Petrópolis-
Descrição: dc.descriptionSanatorio Casa de Galicia-
Descrição: dc.descriptionHospital Nacional Daniel Alcides Carrión Dept. de Medicina Servicio de Nefrología-
Descrição: dc.descriptionMedical Research Unit of Renal Diseases Hospital de Especialidades CMNO IMSS-
Descrição: dc.descriptionBotucatu School of Medicine São Paulo State University-UNESP-
Idioma: dc.languageen-
Relação: dc.relationPLoS ONE-
???dc.source???: dc.sourceScopus-
Título: dc.titleEPILAT-IRA study: A contribution to the understanding of the epidemiology of acute kidney injury in Latin America-
Tipo de arquivo: dc.typelivro digital-
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