A Brazilian multicentre study evaluating pregnancies induced by cabergoline in patients harboring prolactinomas

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorFederal University of Rio de Janeiro-
Autor(es): dc.contributorUniversidade Federal de Pernambuco (UFPE)-
Autor(es): dc.contributorFederal University of Ceara-
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorFederal University of Parana-
Autor(es): dc.contributorIrmandade da Santa Casa de Misericórdia de São Paulo-
Autor(es): dc.contributorHospital de Clinicas de Porto Alegre (UFRGS)-
Autor(es): dc.contributorInstitute of Medical Assistance to the State Public Hospital-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.creatorSant’ Anna, B. G.-
Autor(es): dc.creatorMusolino, N. R.C.-
Autor(es): dc.creatorGadelha, M. R.-
Autor(es): dc.creatorMarques, C.-
Autor(es): dc.creatorCastro, M.-
Autor(es): dc.creatorElias, P. C.L.-
Autor(es): dc.creatorVilar, L.-
Autor(es): dc.creatorLyra, R.-
Autor(es): dc.creatorMartins, M. R.A.-
Autor(es): dc.creatorQuidute, A. R.P.-
Autor(es): dc.creatorAbucham, J.-
Autor(es): dc.creatorNazato, D.-
Autor(es): dc.creatorGarmes, H. M.-
Autor(es): dc.creatorFontana, M. L.C.-
Autor(es): dc.creatorBoguszewski, C. L.-
Autor(es): dc.creatorBueno, C. B.-
Autor(es): dc.creatorCzepielewski, M. A.-
Autor(es): dc.creatorPortes, E. S.-
Autor(es): dc.creatorNunes-Nogueira, V. S. [UNESP]-
Autor(es): dc.creatorRibeiro-Oliveira, A.-
Autor(es): dc.creatorFrancisco, R. P.V.-
Autor(es): dc.creatorBronstein, M. D.-
Autor(es): dc.creatorGlezer, A.-
Data de aceite: dc.date.accessioned2022-02-22T00:32:32Z-
Data de disponibilização: dc.date.available2022-02-22T00:32:32Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s11102-019-01008-z-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201082-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201082-
Descrição: dc.descriptionObjective: To evaluate the maternal–fetal outcomes of CAB-induced pregnancies in patients with prolactinoma in a large cohort. Methods: The prevalence of tumor growth, miscarriage, preterm, low birth weight, congenital malformations and impairment in neuropsychological development in children among women treated with CAB were assessed in a Brazilian multicentre retrospective observational study, Results: We included 194 women with a mean age of 31 (17–45) years, 43.6% presenting microadenomas and 56.4% macroadenomas, at prolactinoma diagnosis. In 233 pregnancies, CAB was withdrawn in 89%, after pregnancy confirmation. Symptoms related to tumor growth occurred in 25 cases, more frequently in macroadenomas. The overall miscarriage rate was 11%, although higher in the subgroup of patients with CAB maintainance after pregnancy confirmation (38% vs. 7.5%). Amongst the live-birth deliveries, preterm occurred in 12%, low birth weight in 6% and congenital malformations in 4.3%. Neuropsychological development impairment was reported in 7% of cases. Conclusions: Our findings confirm previous results of safety in maternal and fetal outcomes in CAB-induced pregnancies; nevertheless, CAB maintenance after pregnancy confirmation was associated with higher miscarriage rate; result that must be further confirmed.-
Descrição: dc.descriptionDivision of Endocrinology and Metabolism Hospital das Clinicas Neuroendocrine Unit University of Sao Paulo Medical School, Av. Dr. Enéas de Carvalho Aguiar, no 155, 8° andar, bloco 3 (Endocrinologia)-
Descrição: dc.descriptionDivision of Neurosurgery Institute of Psychiatry University of Sao Paulo Medical School-
Descrição: dc.descriptionFederal University of Rio de Janeiro-
Descrição: dc.descriptionUniversity of Sao Paulo Medical School of Ribeirao Preto-
Descrição: dc.descriptionFederal University of Pernambuco-
Descrição: dc.descriptionFederal University of Ceara-
Descrição: dc.descriptionEscola Paulista de Medicina Universidade Federal de São Paulo-
Descrição: dc.descriptionState University of Campinas-
Descrição: dc.descriptionEndocrine Division (SEMPR) Department of Internal Medicine Federal University of Parana-
Descrição: dc.descriptionIrmandade da Santa Casa de Misericórdia de São Paulo-
Descrição: dc.descriptionDivision of Endocrinology Hospital de Clinicas de Porto Alegre (UFRGS)-
Descrição: dc.descriptionInstitute of Medical Assistance to the State Public Hospital-
Descrição: dc.descriptionSão Paulo State University (UNESP) Medical School-
Descrição: dc.descriptionFederal University of Minas Gerais-
Descrição: dc.descriptionDisciplina de Obstetrícia Departamento de Obstetrícia e Ginecologia Faculdade de Medicina (FMUSP) Universidade de São Paulo-
Descrição: dc.descriptionSão Paulo State University (UNESP) Medical School-
Formato: dc.format120-128-
Idioma: dc.languageen-
Relação: dc.relationPituitary-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCabergoline-
Palavras-chave: dc.subjectDopamine agonist-
Palavras-chave: dc.subjectMalformation-
Palavras-chave: dc.subjectMiscarriage-
Palavras-chave: dc.subjectPregnancy-
Palavras-chave: dc.subjectProlactinoma-
Título: dc.titleA Brazilian multicentre study evaluating pregnancies induced by cabergoline in patients harboring prolactinomas-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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