Global gene expression profile in canine mammary carcinomas

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorFAMERP-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorVarallo, G. R. [UNESP]-
Autor(es): dc.creatorJardim-Perassi, B. V.-
Autor(es): dc.creatorAlexandre, P. A.-
Autor(es): dc.creatorFukumasu, H.-
Autor(es): dc.creatorZuccari, D. A.P.C.-
Data de aceite: dc.date.accessioned2022-02-22T00:32:32Z-
Data de disponibilização: dc.date.available2022-02-22T00:32:32Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.tvjl.2019.105393-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201077-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201077-
Descrição: dc.descriptionMammary gland tumors are a heterogeneous group of neoplastic diseases. Genetic studies make it possible to determine genetic profiles and identify new molecular markers. The aim of the study was to evaluate the gene expression profile of canine mammary carcinomas and identify potential prognostic markers. Twelve mammary cancer samples from bitches were collected for the evaluation of global gene expression. Microarray assays were performed using commercial kits. Statistical analysis of the microarray was done using moderate t-statistic and adjusted using the Benjamini and Hochberg procedure. Differential connectivity analysis was also performed. Enrichment analyses were conducted using WebGestalt. P-values were calculated using hypergeometric statistics and adjusted using the Benjamini and Hochberg procedure. The HYAL-1 gene was validated using quantitative PCR (qPCR). There were 878 upregulated genes and 821 downregulated genes in the neoplasms studied. Enrichment analysis (individual analysis) identified the HYAL-1 gene as a potential marker of tumorigenesis and tumor recurrence. Differential connectivity analysis demonstrated 262 differentially connected genes.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionPostgraduate Program in Veterinary Surgery UNESP-FCAV, Jaboticabal-
Descrição: dc.descriptionDepartment of Molecular Biology FAMERP, São José do Rio Preto-
Descrição: dc.descriptionDepartment of Veterinary Medicine FZEA-USP, Pirassununga-
Descrição: dc.descriptionPostgraduate Program in Veterinary Surgery UNESP-FCAV, Jaboticabal-
Descrição: dc.descriptionCNPq: 140624/2013-9-
Idioma: dc.languageen-
Relação: dc.relationVeterinary Journal-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDNA microarray-
Palavras-chave: dc.subjectHYAL-1-
Palavras-chave: dc.subjectMammary gland-
Palavras-chave: dc.subjectNeoplasms-
Palavras-chave: dc.subjectPrognosis-
Título: dc.titleGlobal gene expression profile in canine mammary carcinomas-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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