NAMPT levels are inversely related to nitric oxide formation and positively related to soluble fms-like tyrosine kinase-1 levels in preeclampsia

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Mississippi Medical Center-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorPereira, Daniela A.-
Autor(es): dc.creatorSandrim, Valéria C. [UNESP]-
Autor(es): dc.creatorPalei, Ana C.T.-
Autor(es): dc.creatorTanus-Santos, Jose E.-
Autor(es): dc.creatorBelo, Vanessa A.-
Autor(es): dc.creatorCavalli, Ricardo C.-
Autor(es): dc.creatorLuizon, Marcelo R.-
Data de aceite: dc.date.accessioned2022-02-22T00:32:31Z-
Data de disponibilização: dc.date.available2022-02-22T00:32:31Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.preghy.2019.09.022-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201075-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201075-
Descrição: dc.descriptionNAMPT is a biomarker for endothelial dysfunction, but its relationship with nitrite (marker of NO formation) and soluble fms-like tyrosine kinase-1 (sFLT-1) has not been previously evaluated in preeclampsia. Therefore, we measured plasma NAMPT and sFLT-1 levels using enzyme immunoassays and plasma nitrite concentrations using an ozone-based chemiluminescence assay. NAMPT was positively correlated to nitrite (r = 0.217; P = 0.034) and inversely related to sFLT-1 (r = −0.340; P = 0.029) in healthy pregnant women, but inversely related to nitrite (r = −0.259; P = 0.035) and positively correlated to sFLT-1 (r = 0.326; P = 0.007) in preeclamptic patients, suggesting that NAMPT inhibits NO formation and interacts with the antiangiogenic factor sFLT-1 in preeclampsia.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionGraduate Program in Genetics Institute of Biological Sciences Federal University of Minas Gerais (UFMG)-
Descrição: dc.descriptionDepartment of Pharmacology Institute of Biosciences Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionDepartment of Physiology and Biophysics University of Mississippi Medical Center-
Descrição: dc.descriptionDepartment of Pharmacology Ribeirao Preto Medical School University of Sao Paulo-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Ribeirao Preto Medical School University of Sao Paulo-
Descrição: dc.descriptionDepartment of Genetics Ecology and Evolution Institute of Biological Sciences Federal University of Minas Gerais (UFMG)-
Descrição: dc.descriptionDepartment of Pharmacology Institute of Biosciences Universidade Estadual Paulista (UNESP)-
Formato: dc.format137-140-
Idioma: dc.languageen-
Relação: dc.relationPregnancy Hypertension-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectNicotinamide phosphorybosil transferase (NAMPT)-
Palavras-chave: dc.subjectNitric oxide formation-
Palavras-chave: dc.subjectNitrite levels-
Palavras-chave: dc.subjectPreeclampsia-
Palavras-chave: dc.subjectSoluble fms-like tyrosine kinase-1 (sFLT-1)-
Palavras-chave: dc.subjectVisfatin/NAMPT-
Título: dc.titleNAMPT levels are inversely related to nitric oxide formation and positively related to soluble fms-like tyrosine kinase-1 levels in preeclampsia-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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