Development and evaluation of a low-density single-nucleotide polymorphism chip specific to Bos indicus cattle

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorNeogen GeneSeek-
Autor(es): dc.contributorUniversity of Wisconsin-
Autor(es): dc.contributorUniversity of Nebraska-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorFerraz, J. B.S.-
Autor(es): dc.creatorWu, X. L.-
Autor(es): dc.creatorLi, H.-
Autor(es): dc.creatorXu, J.-
Autor(es): dc.creatorFerretti, R.-
Autor(es): dc.creatorSimpson, B.-
Autor(es): dc.creatorWalker, J.-
Autor(es): dc.creatorSilva, L. R.-
Autor(es): dc.creatorGarcia, J. F. [UNESP]-
Autor(es): dc.creatorTait, R. G.-
Autor(es): dc.creatorBauck, S.-
Data de aceite: dc.date.accessioned2022-02-22T00:32:26Z-
Data de disponibilização: dc.date.available2022-02-22T00:32:26Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1071/AN19396-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201040-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201040-
Descrição: dc.descriptionContext: Genomic selection has been of increasing interest in the genetic improvement of Zebu cattle, particularly for quantitative traits that are difficult or expensive to measure, such as carcass traits and meat tenderness. The success of genomic selection depends on several factors, and at its core is the availability of single-nucleotide polymorphism (SNP) chips that are appropriately designed for Bos indicus cattle. However, the currently available commercial bovine SNP chips are mostly designed for Bos taurus cattle. There are two commercial Bos indicus SNP chips; namely, GeneSeek genomic profiler high-density Bos indicus (GGP-HDi) SNP chip and a low-density (LD) Bos indicus SNP chip (Z chip), but these two Bos indicus SNP chips were built with mixed contents of SNPs for Bos indicus and Bos taurus cattle, due to limited availability of genotype data from Bos indicus cattle. Aims: To develop a new GGP indicus 35 000 SNP chip specifically for Bos indicus cattle, which has a low cost, but high accuracy of imputation to Illumina BovineHD chips. Methods: The design of the chip consisted of 34 000 optimally selected SNPs, plus 1000 SNPs pre-reserved for those on the Y chromosome, 'causative' mutations for a variety of economically relevant traits, genetic health conditions and International Society for Animal Genetics globally recognised parentage markers for those breeds of cattle. Key results: The present results showed that this new indicus LD SNP chip had considerably increased minor allele frequencies in indicus breeds than the previous Z-chip. It demonstrated with high imputation accuracy to HD SNP genotypes in five indicus breeds, and with considerable predictability on 14 growth and reproduction traits in Nellore cattle. Conclusions: This new indicus LD chip represented a successful effort to leverage existing knowledge and genotype resources towards the public release of a cost-effective LD SNP chip specifically for Bos indicus cattle, which is expected to replace the previous GGP indicus LD chip and to supplement the existing GGP-HDi 80 000 SNP chip. Implications: A new SNP chip specifically designed for Bos indicus, with high power of imputation to Illumina BovineHD technology and with excellent coverage of the whole genome, is now available on the market for Bos indicus cattle, and Bos indicus and Bos taurus crosses.-
Descrição: dc.descriptionDepartment of Veterinary Medicine College of Animal Science and Food Engineering University of São Paulo Pirassununga, Rua Duque de Caxias Norte, 225-
Descrição: dc.descriptionBiostatistics and Bioinformatics Neogen GeneSeek-
Descrição: dc.descriptionDepartment of Animal Sciences University of Wisconsin-
Descrição: dc.descriptionDepartment of Statistics University of Nebraska-
Descrição: dc.descriptionDepartment of Animal Production and Health College of Veterinary Medicine Unesp-
Descrição: dc.descriptionDepartment of Animal Production and Health College of Veterinary Medicine Unesp-
Idioma: dc.languageen-
Relação: dc.relationAnimal Production Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectgenomic prediction-
Palavras-chave: dc.subjectgrowth-
Palavras-chave: dc.subjectimputation accuracy-
Palavras-chave: dc.subjectreproduction-
Palavras-chave: dc.subjectsingle-nucleotide polymorphism panel-
Palavras-chave: dc.subjectZebu cattle-
Título: dc.titleDevelopment and evaluation of a low-density single-nucleotide polymorphism chip specific to Bos indicus cattle-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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