Bilateral canine seminoma with ocular metastasis: Histochemical and immunohistochemical characterization

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidad Antonio Nariño (UAN)-
Autor(es): dc.contributorUniversidad de Caldas-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorGIDIMEVETZ Universidad Pedagógica y Tecnológica de Colombia-
Autor(es): dc.creatorRivera-Calderón, Luis Gabriel-
Autor(es): dc.creatorMontoya-Flórez, Luis Mauricio-
Autor(es): dc.creatorSilva, Germana A. [UNESP]-
Autor(es): dc.creatorSanctis, Paula [UNESP]-
Autor(es): dc.creatorBelluci, Renata S. [UNESP]-
Autor(es): dc.creatorBrandao, Claudia Valeria [UNESP]-
Autor(es): dc.creatorRocha, Noeme S. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:32:26Z-
Data de disponibilização: dc.date.available2022-02-22T00:32:26Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.24070/bjvp.1983-0246.v13i1p57-61-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201038-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201038-
Descrição: dc.descriptionA 10-year old male dog was examined due to a buphthalmia in the left eye and a nodule in the two testicles. Due to the limited resources of the owner and loss of visual acuity of the patient, the enucleation and castration were chosen as treatment. Microscopic analysis of the testicular tissue revealed neoplastic germ cells. Morphologically, neoplastic cells were characterized by distinct cell borders, scarce and eosinophilic cytoplasm, large round nucleus, with thick chromatin and a prominent nucleolus. Binucleated and multinucleated neoplastic cells were also frequently observed. In 10 high power fields (400x), 62 typical and atypical mitosis were counted. Similar neoplastic cells were identified within the vessels of the retina, sclera and in the sub-epithelial conjunctive tissue of the eyelid. The neoplastic cells observed in the testicle and in the eye were positive for PAS. By immunochemistry technique was identified an intense immunostaining of the neoplastic cells for Vimentin and Ki-67 in both testicular and ocular tissue. While, discrete immunoreactivity was identified to c-KIT from the neoplastic cells in both organs. Based on morphological, histochemical and immunohistochemical analysis, it was possible to characterize the ocular lesion as seminoma metastasis.-
Descrição: dc.descriptionCollege of Veterinary Medicine and Animal Husbandry Universidad Antonio Nariño (UAN)-
Descrição: dc.descriptionFaculty of Veterinary Medicine Universidad Nacional de Colombia Veterinary Pathology Research Group Universidad de Caldas-
Descrição: dc.descriptionDepartment of Veterinary Clinic and Surgery College of Agricultural and Veterinarian Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionPathology College of Medicine from Botucatu São Paulo State University-
Descrição: dc.descriptionDepartment of Veterinary Clinic College of Veterinary Medicine and Animal Husbandry São Paulo State University-
Descrição: dc.descriptionGIDIMEVETZ Universidad Pedagógica y Tecnológica de Colombia-
Descrição: dc.descriptionDepartment of Veterinary Clinic and Surgery College of Agricultural and Veterinarian Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionPathology College of Medicine from Botucatu São Paulo State University-
Descrição: dc.descriptionDepartment of Veterinary Clinic College of Veterinary Medicine and Animal Husbandry São Paulo State University-
Formato: dc.format57-61-
Idioma: dc.languageen-
Relação: dc.relationBrazilian Journal of Veterinary Pathology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectC-KIT-
Palavras-chave: dc.subjectDog-
Palavras-chave: dc.subjectImmunohistochemistry-
Palavras-chave: dc.subjectInhibin-α-
Palavras-chave: dc.subjectKi-67-
Palavras-chave: dc.subjectNeoplasia-
Título: dc.titleBilateral canine seminoma with ocular metastasis: Histochemical and immunohistochemical characterization-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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