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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | University of Illinois at Chicago (UIC) | - |
Autor(es): dc.contributor | Guarulhos University (UNG) | - |
Autor(es): dc.creator | Bim-Júnior, Odair [UNESP] | - |
Autor(es): dc.creator | Gaglieri, Caroline [UNESP] | - |
Autor(es): dc.creator | Bedran-Russo, Ana K. | - |
Autor(es): dc.creator | Bueno-Silva, Bruno | - |
Autor(es): dc.creator | Bannach, Gilbert [UNESP] | - |
Autor(es): dc.creator | Frem, Regina [UNESP] | - |
Autor(es): dc.creator | Ximenes, Valdecir Farias [UNESP] | - |
Autor(es): dc.creator | Lisboa-Filho, Paulo N. [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:32:23Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:32:23Z | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-08-10 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1021/acsbiomaterials.0c00564 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/201027 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/201027 | - |
Descrição: dc.description | Plant-derived compounds incite applications virtually on every biomedical field due to the expedient antioxidant, anti-inflammatory and antimicrobial properties in conjunction with a natural character. Here, quercetin (QCT), a flavonoid with therapeutic potentials relevant to the oral environment, was encapsulated within metal-organic frameworks (MOFs) to address the concept of on-demand release of phytochemicals at the biointerface. We verified the applicability of a microporous MOF (ZIF-8) as a controlled-release system for QCT, as well as investigated the incorporation of QCT@ZIF-8 microparticles into a dental adhesive resin for desirable therapeutic capabilities at the tooth-restoration interface. QCT was encapsulated within the frameworks through a water-based, one-step synthetic process. The resulting QCT@ZIF-8 microparticles were characterized with respect to chemical composition, crystal structure, thermal behavior, micromorphology, and release profile under acidic and physiological conditions. A model dental adhesive formulation was enriched with the bioactive microparticles; both the degree of conversion (DC) of methacrylic double bonds and the polymer thermal behavior were accounted for. The results confirm that crystalline QCT@ZIF-8 microparticles with attractive loading capacities, submicron sizes, high thermal stability and responsiveness to environmental pH change were successfully manufactured. The concentration of QCT@ZIF-8 in the resin system was a key factor to maintain an optimal DC plateau and rate of polymerization. Essentially, one-step encapsulation of QCT in biocompatible ZIF-8 matrices can be easily achieved, and QCT@ZIF-8 microparticles proved as smart platforms to carry bioactive compounds with potential use to prevent microbial and enzymatic degradation of hard tissues and extracellular matrix components. | - |
Descrição: dc.description | Department of Physics School of Sciences São Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Chemistry School of Sciences São Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Restorative Dentistry College of Dentistry University of Illinois at Chicago (UIC) | - |
Descrição: dc.description | Dental Research Division Guarulhos University (UNG) | - |
Descrição: dc.description | Department of Inorganic Chemistry Institute of Chemistry São Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Physics School of Sciences São Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Chemistry School of Sciences São Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Inorganic Chemistry Institute of Chemistry São Paulo State University (UNESP) | - |
Formato: dc.format | 4539-4550 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | ACS Biomaterials Science and Engineering | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | bioactive polymer | - |
Palavras-chave: dc.subject | controlled release | - |
Palavras-chave: dc.subject | dental adhesive | - |
Palavras-chave: dc.subject | flavonoid | - |
Palavras-chave: dc.subject | MOFs | - |
Título: dc.title | MOF-Based Erodible System for On-Demand Release of Bioactive Flavonoid at the Polymer-Tissue Interface | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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