MOF-Based Erodible System for On-Demand Release of Bioactive Flavonoid at the Polymer-Tissue Interface

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Illinois at Chicago (UIC)-
Autor(es): dc.contributorGuarulhos University (UNG)-
Autor(es): dc.creatorBim-Júnior, Odair [UNESP]-
Autor(es): dc.creatorGaglieri, Caroline [UNESP]-
Autor(es): dc.creatorBedran-Russo, Ana K.-
Autor(es): dc.creatorBueno-Silva, Bruno-
Autor(es): dc.creatorBannach, Gilbert [UNESP]-
Autor(es): dc.creatorFrem, Regina [UNESP]-
Autor(es): dc.creatorXimenes, Valdecir Farias [UNESP]-
Autor(es): dc.creatorLisboa-Filho, Paulo N. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:32:23Z-
Data de disponibilização: dc.date.available2022-02-22T00:32:23Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-08-10-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1021/acsbiomaterials.0c00564-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201027-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201027-
Descrição: dc.descriptionPlant-derived compounds incite applications virtually on every biomedical field due to the expedient antioxidant, anti-inflammatory and antimicrobial properties in conjunction with a natural character. Here, quercetin (QCT), a flavonoid with therapeutic potentials relevant to the oral environment, was encapsulated within metal-organic frameworks (MOFs) to address the concept of on-demand release of phytochemicals at the biointerface. We verified the applicability of a microporous MOF (ZIF-8) as a controlled-release system for QCT, as well as investigated the incorporation of QCT@ZIF-8 microparticles into a dental adhesive resin for desirable therapeutic capabilities at the tooth-restoration interface. QCT was encapsulated within the frameworks through a water-based, one-step synthetic process. The resulting QCT@ZIF-8 microparticles were characterized with respect to chemical composition, crystal structure, thermal behavior, micromorphology, and release profile under acidic and physiological conditions. A model dental adhesive formulation was enriched with the bioactive microparticles; both the degree of conversion (DC) of methacrylic double bonds and the polymer thermal behavior were accounted for. The results confirm that crystalline QCT@ZIF-8 microparticles with attractive loading capacities, submicron sizes, high thermal stability and responsiveness to environmental pH change were successfully manufactured. The concentration of QCT@ZIF-8 in the resin system was a key factor to maintain an optimal DC plateau and rate of polymerization. Essentially, one-step encapsulation of QCT in biocompatible ZIF-8 matrices can be easily achieved, and QCT@ZIF-8 microparticles proved as smart platforms to carry bioactive compounds with potential use to prevent microbial and enzymatic degradation of hard tissues and extracellular matrix components.-
Descrição: dc.descriptionDepartment of Physics School of Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Chemistry School of Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Restorative Dentistry College of Dentistry University of Illinois at Chicago (UIC)-
Descrição: dc.descriptionDental Research Division Guarulhos University (UNG)-
Descrição: dc.descriptionDepartment of Inorganic Chemistry Institute of Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Physics School of Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Chemistry School of Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Inorganic Chemistry Institute of Chemistry São Paulo State University (UNESP)-
Formato: dc.format4539-4550-
Idioma: dc.languageen-
Relação: dc.relationACS Biomaterials Science and Engineering-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbioactive polymer-
Palavras-chave: dc.subjectcontrolled release-
Palavras-chave: dc.subjectdental adhesive-
Palavras-chave: dc.subjectflavonoid-
Palavras-chave: dc.subjectMOFs-
Título: dc.titleMOF-Based Erodible System for On-Demand Release of Bioactive Flavonoid at the Polymer-Tissue Interface-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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