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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Pontificia Universidad Católica de Chile | - |
Autor(es): dc.contributor | Universidad de Valparaíso | - |
Autor(es): dc.contributor | Pontificia Universidad Javeriana | - |
Autor(es): dc.contributor | University of Alberta | - |
Autor(es): dc.contributor | Universidad del Bío-Bío | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Universidad de Talca | - |
Autor(es): dc.contributor | Venezuelan Institute for Scientific Research (IVIC) | - |
Autor(es): dc.contributor | Universidad de Sevilla | - |
Autor(es): dc.contributor | University of Queensland | - |
Autor(es): dc.creator | Sobrevia, Luis | - |
Autor(es): dc.creator | Valero, Paola | - |
Autor(es): dc.creator | Grismaldo, Adriana | - |
Autor(es): dc.creator | Villalobos-Labra, Roberto | - |
Autor(es): dc.creator | Pardo, Fabián | - |
Autor(es): dc.creator | Subiabre, Mario | - |
Autor(es): dc.creator | Armstrong, Gael | - |
Autor(es): dc.creator | Toledo, Fernando | - |
Autor(es): dc.creator | Vega, Sofía [UNESP] | - |
Autor(es): dc.creator | Cornejo, Marcelo | - |
Autor(es): dc.creator | Fuentes, Gonzalo | - |
Autor(es): dc.creator | Marín, Reinaldo | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:32:21Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:32:21Z | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-11-30 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1016/j.bbadis.2020.165948 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/201019 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/201019 | - |
Descrição: dc.description | Gestational diabetes mellitus (GDM) is a disease of pregnancy that is associated with D-glucose intolerance and foeto-placental vascular dysfunction. GMD causes mitochondrial dysfunction in the placental endothelium and trophoblast. Additionally, GDM is associated with reduced placental oxidative phosphorylation due to diminished activity of the mitochondrial F0F1-ATP synthase (complex V). This phenomenon may result from a higher generation of reactive superoxide anion and nitric oxide. Placental mitochondrial biogenesis and mitophagy work in concert to maintain cell homeostasis and are vital mechanisms securing the efficient generation of ATP, whose demand is higher in pregnancy, ensuring foetal growth and development. Additional factors disturbing placental ATP synthase activity in GDM include pre-gestational maternal obesity or overweight, intracellular pH, miRNAs, fatty acid oxidation, and foetal (and ‘placental’) sex. GDM is also associated with maternal and foetal hyperinsulinaemia, altered circulating levels of adiponectin and leptin, and the accumulation of extracellular adenosine. Here, we reviewed the potential interplay between these molecules or metabolic conditions on the mechanisms of mitochondrial dysfunction in the foeto-placental unit in GDM pregnancies. | - |
Descrição: dc.description | Fondo Nacional de Desarrollo Científico y Tecnológico | - |
Descrição: dc.description | Fondo Nacional de Ciencia Tecnología e Innovación | - |
Descrição: dc.description | Cellular and Molecular Physiology Laboratory (CMPL) Department of Obstetrics Division of Obstetrics and Gynaecology School of Medicine Faculty of Medicine Pontificia Universidad Católica de Chile | - |
Descrição: dc.description | Faculty of Science Faculty of Engineering Faculty of Medicine Universidad de Valparaíso | - |
Descrição: dc.description | Faculty of Sciences Department of Nutrition and Biochemistry Pontificia Universidad Javeriana | - |
Descrição: dc.description | Department of Obstetrics and Gynaecology Heritage Medical Research Centre (HMRC) University of Alberta | - |
Descrição: dc.description | Metabolic Diseases Research Laboratory Interdisciplinary Centre of Territorial Health Research (CIISTe) Biomedical Research Center (CIB) San Felipe Campus School of Medicine Faculty of Medicine Universidad de Valparaíso | - |
Descrição: dc.description | Department of Basic Sciences Faculty of Sciences Universidad del Bío-Bío | - |
Descrição: dc.description | Department of Gynaecology and Obstetrics Botucatu Medical School (FMB) São Paulo State University (UNESP) | - |
Descrição: dc.description | Faculty of Health Sciences Universidad de Talca | - |
Descrição: dc.description | Laboratory of Cell Bioenergetics Center for Biophysics and Biochemistry (CBB) Venezuelan Institute for Scientific Research (IVIC), AP 21827 | - |
Descrição: dc.description | Department of Physiology Faculty of Pharmacy Universidad de Sevilla | - |
Descrição: dc.description | University of Queensland Centre for Clinical Research (UQCCR) Faculty of Medicine and Biomedical Sciences University of Queensland | - |
Descrição: dc.description | Department of Gynaecology and Obstetrics Botucatu Medical School (FMB) São Paulo State University (UNESP) | - |
Descrição: dc.description | Fondo Nacional de Desarrollo Científico y Tecnológico: 1190316 | - |
Descrição: dc.description | Fondo Nacional de Ciencia Tecnología e Innovación: F-2005000222 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Biochimica et Biophysica Acta - Molecular Basis of Disease | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | Adenosine | - |
Palavras-chave: dc.subject | Endothelium | - |
Palavras-chave: dc.subject | Gestational diabetes | - |
Palavras-chave: dc.subject | Human | - |
Palavras-chave: dc.subject | Insulin | - |
Palavras-chave: dc.subject | Mitochondria | - |
Palavras-chave: dc.subject | Placenta | - |
Título: dc.title | Mitochondrial dysfunction in the fetoplacental unit in gestational diabetes mellitus | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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