Mitochondrial dysfunction in the fetoplacental unit in gestational diabetes mellitus

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorPontificia Universidad Católica de Chile-
Autor(es): dc.contributorUniversidad de Valparaíso-
Autor(es): dc.contributorPontificia Universidad Javeriana-
Autor(es): dc.contributorUniversity of Alberta-
Autor(es): dc.contributorUniversidad del Bío-Bío-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidad de Talca-
Autor(es): dc.contributorVenezuelan Institute for Scientific Research (IVIC)-
Autor(es): dc.contributorUniversidad de Sevilla-
Autor(es): dc.contributorUniversity of Queensland-
Autor(es): dc.creatorSobrevia, Luis-
Autor(es): dc.creatorValero, Paola-
Autor(es): dc.creatorGrismaldo, Adriana-
Autor(es): dc.creatorVillalobos-Labra, Roberto-
Autor(es): dc.creatorPardo, Fabián-
Autor(es): dc.creatorSubiabre, Mario-
Autor(es): dc.creatorArmstrong, Gael-
Autor(es): dc.creatorToledo, Fernando-
Autor(es): dc.creatorVega, Sofía [UNESP]-
Autor(es): dc.creatorCornejo, Marcelo-
Autor(es): dc.creatorFuentes, Gonzalo-
Autor(es): dc.creatorMarín, Reinaldo-
Data de aceite: dc.date.accessioned2022-02-22T00:32:21Z-
Data de disponibilização: dc.date.available2022-02-22T00:32:21Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.bbadis.2020.165948-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201019-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201019-
Descrição: dc.descriptionGestational diabetes mellitus (GDM) is a disease of pregnancy that is associated with D-glucose intolerance and foeto-placental vascular dysfunction. GMD causes mitochondrial dysfunction in the placental endothelium and trophoblast. Additionally, GDM is associated with reduced placental oxidative phosphorylation due to diminished activity of the mitochondrial F0F1-ATP synthase (complex V). This phenomenon may result from a higher generation of reactive superoxide anion and nitric oxide. Placental mitochondrial biogenesis and mitophagy work in concert to maintain cell homeostasis and are vital mechanisms securing the efficient generation of ATP, whose demand is higher in pregnancy, ensuring foetal growth and development. Additional factors disturbing placental ATP synthase activity in GDM include pre-gestational maternal obesity or overweight, intracellular pH, miRNAs, fatty acid oxidation, and foetal (and ‘placental’) sex. GDM is also associated with maternal and foetal hyperinsulinaemia, altered circulating levels of adiponectin and leptin, and the accumulation of extracellular adenosine. Here, we reviewed the potential interplay between these molecules or metabolic conditions on the mechanisms of mitochondrial dysfunction in the foeto-placental unit in GDM pregnancies.-
Descrição: dc.descriptionFondo Nacional de Desarrollo Científico y Tecnológico-
Descrição: dc.descriptionFondo Nacional de Ciencia Tecnología e Innovación-
Descrição: dc.descriptionCellular and Molecular Physiology Laboratory (CMPL) Department of Obstetrics Division of Obstetrics and Gynaecology School of Medicine Faculty of Medicine Pontificia Universidad Católica de Chile-
Descrição: dc.descriptionFaculty of Science Faculty of Engineering Faculty of Medicine Universidad de Valparaíso-
Descrição: dc.descriptionFaculty of Sciences Department of Nutrition and Biochemistry Pontificia Universidad Javeriana-
Descrição: dc.descriptionDepartment of Obstetrics and Gynaecology Heritage Medical Research Centre (HMRC) University of Alberta-
Descrição: dc.descriptionMetabolic Diseases Research Laboratory Interdisciplinary Centre of Territorial Health Research (CIISTe) Biomedical Research Center (CIB) San Felipe Campus School of Medicine Faculty of Medicine Universidad de Valparaíso-
Descrição: dc.descriptionDepartment of Basic Sciences Faculty of Sciences Universidad del Bío-Bío-
Descrição: dc.descriptionDepartment of Gynaecology and Obstetrics Botucatu Medical School (FMB) São Paulo State University (UNESP)-
Descrição: dc.descriptionFaculty of Health Sciences Universidad de Talca-
Descrição: dc.descriptionLaboratory of Cell Bioenergetics Center for Biophysics and Biochemistry (CBB) Venezuelan Institute for Scientific Research (IVIC), AP 21827-
Descrição: dc.descriptionDepartment of Physiology Faculty of Pharmacy Universidad de Sevilla-
Descrição: dc.descriptionUniversity of Queensland Centre for Clinical Research (UQCCR) Faculty of Medicine and Biomedical Sciences University of Queensland-
Descrição: dc.descriptionDepartment of Gynaecology and Obstetrics Botucatu Medical School (FMB) São Paulo State University (UNESP)-
Descrição: dc.descriptionFondo Nacional de Desarrollo Científico y Tecnológico: 1190316-
Descrição: dc.descriptionFondo Nacional de Ciencia Tecnología e Innovación: F-2005000222-
Idioma: dc.languageen-
Relação: dc.relationBiochimica et Biophysica Acta - Molecular Basis of Disease-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAdenosine-
Palavras-chave: dc.subjectEndothelium-
Palavras-chave: dc.subjectGestational diabetes-
Palavras-chave: dc.subjectHuman-
Palavras-chave: dc.subjectInsulin-
Palavras-chave: dc.subjectMitochondria-
Palavras-chave: dc.subjectPlacenta-
Título: dc.titleMitochondrial dysfunction in the fetoplacental unit in gestational diabetes mellitus-
Aparece nas coleções:Repositório Institucional - Unesp

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