Design of chitosan-based particle systems: A review of the physicochemical foundations for tailored properties

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorFerreira, Leonardo M.B.-
Autor(es): dc.creatordos Santos, Aline M. [UNESP]-
Autor(es): dc.creatorBoni, Fernanda Isadora [UNESP]-
Autor(es): dc.creatordos Santos, Karen C. [UNESP]-
Autor(es): dc.creatorRobusti, Leda M. Gorla [UNESP]-
Autor(es): dc.creatorde Souza, Maurício P.C. [UNESP]-
Autor(es): dc.creatorFerreira, Natália N. [UNESP]-
Autor(es): dc.creatorCarvalho, Suzana G. [UNESP]-
Autor(es): dc.creatorCardoso, Valéria M.O. [UNESP]-
Autor(es): dc.creatorChorilli, Marlus [UNESP]-
Autor(es): dc.creatorCury, Beatriz S.F. [UNESP]-
Autor(es): dc.creatorde Godoi, Denis R.M. [UNESP]-
Autor(es): dc.creatorGremião, Maria Palmira D. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:32:19Z-
Data de disponibilização: dc.date.available2022-02-22T00:32:19Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-14-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.carbpol.2020.116968-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201003-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201003-
Descrição: dc.descriptionChitosan-based particles are widely proposed as biocompatible drug delivery systems with mucoadhesive and permeation enhancing properties. However, strategies on how to modulate the intended biological responses are still scarce. Considering that particle properties affect the biological outcome, the rational design of the synthesis variables should be proposed to engineer drug delivery systems with improved biological performance. The purpose of this review is to establish a deeper understanding of possible correlations between these variables and the particle properties from theoretical and experimental perspectives. The fundamental physicochemical knowledge of chitosan-based polyelectrolyte complexation and surface modification is discussed focusing on chitosan-TPP, polyelectrolyte complexes, and chitosan-surface modified PLGA or lipid particles. A set of design considerations is proposed to enable future investigation in the development of chitosan particles with modulated properties. The approach presented here contributes to the rational design of chitosan-based particles that meet different requirements for biological activities.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionGroup of Nanomedicine and Nanotoxicology São Carlos Institute of Physics University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Drugs and Pharmaceutics School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Physicochemistry Institute of Chemistry of Araraquara São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Drugs and Pharmaceutics School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Physicochemistry Institute of Chemistry of Araraquara São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationCarbohydrate Polymers-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectChitosan particles-
Palavras-chave: dc.subjectPolysaccharides-
Palavras-chave: dc.subjectRational design-
Palavras-chave: dc.subjectSelf-assembly-
Palavras-chave: dc.subjectSupramolecular chemistry-
Palavras-chave: dc.subjectThermodynamics-
Título: dc.titleDesign of chitosan-based particle systems: A review of the physicochemical foundations for tailored properties-
Aparece nas coleções:Repositório Institucional - Unesp

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