Functional haplotype in the Interleukin8 (CXCL8) gene is associated with type 2 Diabetes Mellitus and Periodontitis in Brazilian population

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUnion of the Colleges of the Great Lakes (UNILAGO)-
Autor(es): dc.contributorSchool of Dentistry-
Autor(es): dc.creatorSilva, Bárbara Roque da [UNESP]-
Autor(es): dc.creatorCirelli, Thamiris [UNESP]-
Autor(es): dc.creatorNepomuceno, Rafael [UNESP]-
Autor(es): dc.creatorTheodoro, Letícia Helena [UNESP]-
Autor(es): dc.creatorOrrico, Silvana R.P. [UNESP]-
Autor(es): dc.creatorCirelli, Joni A. [UNESP]-
Autor(es): dc.creatorBarros, Silvana P.-
Autor(es): dc.creatorScarel-Caminaga, Raquel M. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:32:18Z-
Data de disponibilização: dc.date.available2022-02-22T00:32:18Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.dsx.2020.08.036-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200997-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200997-
Descrição: dc.descriptionBackground and aim: Type 2 Diabetes Mellitus (T2DM) and Periodontitis (P) are prevalent multifactorial disorders worldwide, sharing a bidirectional relationship influenced by the genetic susceptibility of the host immune system. We investigated whether SNPs in the Interleukin 8 (IL8, alias CXCL8) gene could be associated with T2DM and Periodontitis. Methods: Genomic DNA was obtained from 874 Brazilian individuals divided into: Healthy group (n = 307), Periodontitis group (n = 334), and individuals affected by both T2DM and Periodontitis (T2DM_P) group (n = 233). The SNPs −251(T>A) rs4073, +396(T>G) rs2227307 and +781(C>T) rs2227306 were genotyped by TaqMan®. Multiple logistic regressions were used to determine the degree of association between polymorphisms (and haplotypes) with periodontitis and T2DM adjusted for known confounders. Results: The additive model revealed that the heterozygous AT(-251), GT(+396) and CT(+781) genotypes showed a lower risk for the diseased phenotypes, and carriers of the TTC/TTC haplotype were significantly susceptible to T2DM and Periodontitis concomitantly, as well to isolated Periodontitis (mainly the severe form). Conclusions: We concluded, for the first time, that these functional CXCL8 SNPs, and the homozygous TTC haplotype are relevant genetic factors for T2DM and Periodontitis as comorbidities, as well as for severe Periodontitis susceptibility in Brazilian population.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery São Paulo State University – UNESP School of Dentistry at Araraquara-
Descrição: dc.descriptionDepartment of Morphology Genetics Orthodontics and Pediatric Dentistry São Paulo State University – UNESP School of Dentistry at Araraquara-
Descrição: dc.descriptionDepartment of Surgery and Integrated Clinic São Paulo State University – UNESP School of Dentistry at Araçatuba-
Descrição: dc.descriptionAdvanced Research Center in Medicine Union of the Colleges of the Great Lakes (UNILAGO)-
Descrição: dc.descriptionDepartment of Comprehensive Oral Health - Periodontology University of North Carolina at Chapel Hill – UNC School of Dentistry-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery São Paulo State University – UNESP School of Dentistry at Araraquara-
Descrição: dc.descriptionDepartment of Morphology Genetics Orthodontics and Pediatric Dentistry São Paulo State University – UNESP School of Dentistry at Araraquara-
Descrição: dc.descriptionDepartment of Surgery and Integrated Clinic São Paulo State University – UNESP School of Dentistry at Araçatuba-
Descrição: dc.descriptionFAPESP: 2014/13295-1-
Descrição: dc.descriptionFAPESP: 2016/03753-8-
Descrição: dc.descriptionFAPESP: 2016/08070-6-
Descrição: dc.descriptionFAPESP: 2016/18313-3-
Descrição: dc.descriptionFAPESP: 2016/25418-6-
Descrição: dc.descriptionFAPESP: 2018/26367-1-
Descrição: dc.descriptionCNPq: 304570/2017-6-
Descrição: dc.descriptionCNPq: 445336/2014-5-
Formato: dc.format1665-1672-
Idioma: dc.languageen-
Relação: dc.relationDiabetes and Metabolic Syndrome: Clinical Research and Reviews-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDiabetes mellitus-
Palavras-chave: dc.subjectGenetic polymorphisms-
Palavras-chave: dc.subjectHaplotypes-
Palavras-chave: dc.subjectInterleukin-
Palavras-chave: dc.subjectPeriodontitis-
Título: dc.titleFunctional haplotype in the Interleukin8 (CXCL8) gene is associated with type 2 Diabetes Mellitus and Periodontitis in Brazilian population-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.