Citrinin against breast cancer: A cytogenotoxicological study

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Piauí – UFPI-
Autor(es): dc.contributorFederal University of Piauí-
Autor(es): dc.contributorFederal Institute of Piauí (IFPI)-
Autor(es): dc.contributorScience and Technology of Maranhão (IFMA)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorFederal University of Maranhão-
Autor(es): dc.contributorTon Duc Thang University-
Autor(es): dc.contributorThe University of Jordan-
Autor(es): dc.creatorde Oliveira Filho, José Williams Gomes-
Autor(es): dc.creatorAndrade, Teresinha de Jesus Aguiar dos Santos-
Autor(es): dc.creatorde Lima, Rosália Maria Tôrres-
Autor(es): dc.creatordos Reis, Antonielly Campinho-
Autor(es): dc.creatorSilva, Dulce Helena Siqueira [UNESP]-
Autor(es): dc.creatorSantos, José Victor de Oliveira-
Autor(es): dc.creatorde Menezes, Ag-Anne Pereira Melo-
Autor(es): dc.creatorda Mata, Ana Maria Oliveira-
Autor(es): dc.creatorDias, Ana Carolina Soares-
Autor(es): dc.creatorde Alencar, Marcus Vinícius Oliveira Barros-
Autor(es): dc.creatorPaz, Márcia Fernanda Correia Jardim-
Autor(es): dc.creatorMoreno, Lina Clara Gayoso e Almendra Ibiapina-
Autor(es): dc.creatorIslam, Muhammad Torequl-
Autor(es): dc.creatorMubarak, Mohammad S.-
Autor(es): dc.creatorSousa, João Marcelo de Castro e-
Autor(es): dc.creatorMelo Cavalcante, Ana Amélia de Carvalho-
Data de aceite: dc.date.accessioned2022-02-22T00:32:14Z-
Data de disponibilização: dc.date.available2022-02-22T00:32:14Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/ptr.6830-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200969-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200969-
Descrição: dc.descriptionBreast cancer is one of the most lethal types of cancer and a leading cause of mortality among Women worldwide. Citrinin (CIT), a polyketide extracted from the fungus Penicillium citrinum, exhibits a wide range of biological activities such as antibacterial, antifungal, and cytotoxic effects. The aim of the current study was to evaluate the antitumoral effects of CIT against 7,12-dimethylbenzanthracene (DMBA)-induced mammary carcinoma in Swiss mice For this, CIT, DMBA and the standard cyclophosphamide (CPA) induced behavioral changes in experimental animals, and these changes were screened by using the rota rod and open field tests. Additionally, hematological, biochemical, immuno-histochemical, and histopathological analyses were carried out. Results suggest that CIT did not alter behavioral, hematological, and biochemical parameters in mice. DMBA induced invasive mammary carcinoma and showed genotoxic effects in the breasts, bone marrow, lymphocytes, and hepatic cells. It also caused mutagenic effects in the formation of micronuclei, bridges, shoots, and binucleate cells in bone marrow and liver. CIT and CPA genotoxic effects were observed after 3 weeks of therapy, where CIT exhibited a repair capacity and induced significant apoptotic damage in mouse lymphocytes. In conclusion, CIT showed antitumoral effects in Swiss mice, possibly through induction of apoptosis.-
Descrição: dc.descriptionNortheast Biotechnology Network (RENORBIO) Postgraduate Program in Biotechnology Federal University of Piauí – UFPI-
Descrição: dc.descriptionLaboratory of Research in Toxicological Genetics – LAPGENIC Federal University of Piauí-
Descrição: dc.descriptionFederal Institute of Piauí (IFPI)-
Descrição: dc.descriptionNucleus of Applied Research to Sciences (NIAC) Federal Institute of Education Science and Technology of Maranhão (IFMA)-
Descrição: dc.descriptionNucleus of Bioassays Biosynthesis and Ecophysiology of Natural Products (NuBBE) Department of Organic Chemistry Institute of Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionLaboratory of Genetics and Molecular Biology Federal University of Maranhão-
Descrição: dc.descriptionLaboratory of Pharmaceutical Nanosystems – NANOSFAR Federal University of Piauí-
Descrição: dc.descriptionLaboratory of Theoretical and Computational Biophysics Ton Duc Thang University-
Descrição: dc.descriptionFaculty of Pharmacy Ton Duc Thang University-
Descrição: dc.descriptionDepartment of Chemistry The University of Jordan-
Descrição: dc.descriptionNucleus of Bioassays Biosynthesis and Ecophysiology of Natural Products (NuBBE) Department of Organic Chemistry Institute of Chemistry São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationPhytotherapy Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectanticancer drug-
Palavras-chave: dc.subjectbreast cancer-
Palavras-chave: dc.subjectcitrinin-
Palavras-chave: dc.subjectMus musculus-
Palavras-chave: dc.subjectmycotoxin-
Título: dc.titleCitrinin against breast cancer: A cytogenotoxicological study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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