The role of sodium alginate and gellan gum in the design of new drug delivery systems intended for antibiofilm activity of morin

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Araraquara - UNIARA-
Autor(es): dc.creatorde Farias, Aline Leite [UNESP]-
Autor(es): dc.creatorMeneguin, Andréia Bagliotti [UNESP]-
Autor(es): dc.creatorda Silva Barud, Hernane-
Autor(es): dc.creatorBrighenti, Fernanda Lourenção [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:32:11Z-
Data de disponibilização: dc.date.available2022-02-22T00:32:11Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ijbiomac.2020.08.078-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200950-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200950-
Descrição: dc.descriptionThe use of controlled drug delivery systems represents an alternative and promising strategy for the use of antimicrobials in the oral cavity. Microparticles, films and oral tablets based on alginate and gellan gum were developed also as a strategy to overcome the low aqueous solubility of morin. The systems were characterized in terms of morphological characteristics, mucoadhesion and in vitro drug release. Antibiofilm activity was analyzed for acidogenicity, microbial viability and the composition of the extracellular matrix of single-species biofilms. Scanning Electron Microscopy demonstrated that the microparticles were spherical, rough and compact. The film and the tablet presented smooth and continuous surface and in the inner of the tablet was porous. These systems were more mucoadhesive compared to the microparticles. The in vitro morin release profiles in artificial saliva demonstrated that the microparticles controlled the release better (39.6%), followed by the film (41.1%) and the tablet (91.4%) after 20 h of testing. The morin released from the systems reduced the acidogenicity, microbial viability, concentration of insoluble extracellular polysaccharides and dry weight of biofilms, when compared to the control group. The findings of this study showed that the morin has antibiofilm activity against cariogenic microorganisms.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Morphology Pediatric Dentistry and Orthodontics School of Dentistry São Paulo State University - UNESP-
Descrição: dc.descriptionDepartment of Drugs and Pharmaceuticals School of Pharmaceutical Sciences São Paulo State University-UNESP-
Descrição: dc.descriptionBiopolymers and Biomaterials Laboratory (BioPolMat) University of Araraquara - UNIARA-
Descrição: dc.descriptionDepartment of Morphology Pediatric Dentistry and Orthodontics School of Dentistry São Paulo State University - UNESP-
Descrição: dc.descriptionDepartment of Drugs and Pharmaceuticals School of Pharmaceutical Sciences São Paulo State University-UNESP-
Descrição: dc.descriptionFAPESP: 2013/07276-1-
Descrição: dc.descriptionFAPESP: 2013/12326-8-
Descrição: dc.descriptionFAPESP: 2018/25512-8-
Descrição: dc.descriptionCNPq: 304383/2016­3-
Descrição: dc.descriptionCNPq: 407822/2018-6-
Descrição: dc.descriptionFAPESP: CEPID - 13/07276-1-
Formato: dc.format1944-1958-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Biological Macromolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAlginate-
Palavras-chave: dc.subjectControlled drug delivery-
Palavras-chave: dc.subjectDental plaque-
Palavras-chave: dc.subjectGellan gum-
Palavras-chave: dc.subjectMorin hydrate-
Palavras-chave: dc.subjectPolysaccharides-
Título: dc.titleThe role of sodium alginate and gellan gum in the design of new drug delivery systems intended for antibiofilm activity of morin-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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