Transient Foxp3(+) regulatory T-cell depletion enhances protective Th1/Th17 immune response in murine sporotrichosis caused by Sporothrix schenckii

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorBatista-Duharte, Alexander [UNESP]-
Autor(es): dc.creatorTéllez-Martínez, Damiana [UNESP]-
Autor(es): dc.creatorde Andrade, Cleverton Roberto [UNESP]-
Autor(es): dc.creatorPolesi, Marisa Campos [UNESP]-
Autor(es): dc.creatorPortuondo, Deivys Leandro [UNESP]-
Autor(es): dc.creatorCarlos, Iracilda Zeppone [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:32:10Z-
Data de disponibilização: dc.date.available2022-02-22T00:32:10Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.imbio.2020.151993-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200944-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200944-
Descrição: dc.descriptionThe role of regulatory T cells (Tregs) on protective immunity in fungal infections, is controversial. Sporotrichosis is an emerging and worldwide-distributed subcutaneous mycosis caused by various related thermodimorphic fungi of the genus Sporothrix. Previously, we showed an elevated percent of Tregs around 21 days post-infection (dpi) in C57BL/6 mice infected with either Sporothrix schenckii or Sporothrix brasiliensis, but the effect of these cells in the ongoing infection was not evaluated. Here, we aim to characterize the role of Foxp3+ Tregs in a subcutaneous S. schenckii infection model. The flow cytometric analyses showed that S. schenckii infection elicited an expansion of a splenic CD4+Foxp3+ population, including a subset of Helioslow+ after ex vivo stimulation with S. schenckii-heat killed yeast. Depletion of Tregs in DEREG mice revealed a reduction of fungal burden in the skin and systemically in liver and kidneys, associated with enhanced Th1 and Th17 responses. Altogether, our results reveal for the first time that Tregs depletion in ongoing S. schenckii infection improves the protective antifungal immunity and these data suggest that Tregs modulation could be explored as a potential therapeutic strategy in sporotrichosis.-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences Department of Clinical Analysis-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Dentistry Department of Physiology & Pathology-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences Department of Clinical Analysis-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Dentistry Department of Physiology & Pathology-
Idioma: dc.languageen-
Relação: dc.relationImmunobiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDEREG mice-
Palavras-chave: dc.subjectFoxp3-
Palavras-chave: dc.subjectHelios-
Palavras-chave: dc.subjectRegulatory T cells-
Palavras-chave: dc.subjectSporothrix schenckii-
Palavras-chave: dc.subjectSporotrichosis-
Título: dc.titleTransient Foxp3(+) regulatory T-cell depletion enhances protective Th1/Th17 immune response in murine sporotrichosis caused by Sporothrix schenckii-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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