Hla-C genetic diversity and evolutionary insights in two samples from Brazil and Benin

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversité de Paris-
Autor(es): dc.contributorCentre d'Etude et de Recherche sur le Paludisme Associé à la Grossesse et à l'Enfance-
Autor(es): dc.contributorUniversité d'Abomey-Calavi-
Autor(es): dc.creatorSouza, Andreia S. [UNESP]-
Autor(es): dc.creatorSonon, Paulin-
Autor(es): dc.creatorPaz, Michelle A. [UNESP]-
Autor(es): dc.creatorTokplonou, Léonidas-
Autor(es): dc.creatorLima, Thálitta H. A. [UNESP]-
Autor(es): dc.creatorPorto, Iane O. P. [UNESP]-
Autor(es): dc.creatorAndrade, Heloisa S. [UNESP]-
Autor(es): dc.creatorSilva, Nayane dos S. B. [UNESP]-
Autor(es): dc.creatorVeiga-Castelli, Luciana C.-
Autor(es): dc.creatorOliveira, Maria Luiza G.-
Autor(es): dc.creatorSadissou, Ibrahim Abiodoun-
Autor(es): dc.creatorMassaro, Juliana Doblas-
Autor(es): dc.creatorMoutairou, Kabirou A.-
Autor(es): dc.creatorDonadi, Eduardo A.-
Autor(es): dc.creatorMassougbodji, Achille-
Autor(es): dc.creatorGarcia, André-
Autor(es): dc.creatorIbikounlé, Moudachirou-
Autor(es): dc.creatorMeyer, Diogo-
Autor(es): dc.creatorSabbagh, Audrey-
Autor(es): dc.creatorMendes-Junior, Celso T.-
Autor(es): dc.creatorCourtin, David-
Autor(es): dc.creatorCastelli, Erick C. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:32:09Z-
Data de disponibilização: dc.date.available2022-02-22T00:32:09Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/tan.13996-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200938-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200938-
Descrição: dc.descriptionHuman leukocyte antigen-C (HLA-C) is a classical HLA class I molecule that binds and presents peptides to cytotoxic T lymphocytes in the cell surface. HLA-C has a dual function because it also interacts with Killer-cell immunoglobulin-like receptors (KIR) receptors expressed in natural killer and T cells, modulating their activity. The structure and diversity of the HLA-C regulatory regions, as well as the relationship among variants along the HLA-C locus, are poorly addressed, and few population-based studies explored the HLA-C variability in the entire gene in different population samples. Here we present a molecular and bioinformatics method to evaluate the entire HLA-C diversity, including regulatory sequences. Then, we applied this method to survey the HLA-C diversity in two population samples with different demographic histories, one highly admixed from Brazil with major European contribution, and one from Benin with major African contribution. The HLA-C promoter and 3′UTR were very polymorphic with the presence of few, but highly divergent haplotypes. These segments also present conserved sequences that are shared among different primate species. Nucleotide diversity was higher in other segments rather than exons 2 and 3, particularly around exon 5 and the second half of the 3′UTR region. We detected evidence of balancing selection on the entire HLA-C locus and positive selection in the HLA-C leader peptide, for both populations. HLA-C motifs previously associated with KIR interaction and expression regulation are similar between both populations. Each allele group is associated with specific regulatory sequences, reflecting the high linkage disequilibrium along the entire HLA-C locus in both populations.-
Descrição: dc.descriptionMolecular Genetics and Bioinformatics Laboratory—Experimental Research Unity School of Medicine São Paulo State University (UNESP)-
Descrição: dc.descriptionGenetics Program Institute of Biosciences of Botucatu São Paulo State University (UNESP)-
Descrição: dc.descriptionLaboratório de Biologia Molecular Programa de Imunologia Básica e Aplicada (IBA) Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo (USP)-
Descrição: dc.descriptionPathology Program School of Medicine São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitut de Recherche pour le Développement (IRD) UMR 261 MERIT Université de Paris-
Descrição: dc.descriptionCentre d'Etude et de Recherche sur le Paludisme Associé à la Grossesse et à l'Enfance-
Descrição: dc.descriptionDépartement de Zoologie Faculté des Sciences et Techniques Université d'Abomey-Calavi-
Descrição: dc.descriptionDepartment of Genetics School of Medicine of Ribeirão Preto University of São Paulo (USP)-
Descrição: dc.descriptionLaboratoire de Biologie et Physiologie Cellulaire Université d'Abomey-Calavi-
Descrição: dc.descriptionDepartment of Medicine School of Medicine of Ribeirão Preto University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Genetics and Evolutionary Biology University of São Paulo (USP)-
Descrição: dc.descriptionDepartamento de Química Faculdade de Filosofia Ciências e Letras de Ribeirão Preto Universidade de São Paulo (USP)-
Descrição: dc.descriptionMolecular Genetics and Bioinformatics Laboratory—Experimental Research Unity School of Medicine São Paulo State University (UNESP)-
Descrição: dc.descriptionGenetics Program Institute of Biosciences of Botucatu São Paulo State University (UNESP)-
Descrição: dc.descriptionPathology Program School of Medicine São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationHLA-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBeninese population-
Palavras-chave: dc.subjectBrazilian population-
Palavras-chave: dc.subjectHLA-C-
Palavras-chave: dc.subjectnatural selection-
Palavras-chave: dc.subjectNGS-
Palavras-chave: dc.subjectvariability-
Título: dc.titleHla-C genetic diversity and evolutionary insights in two samples from Brazil and Benin-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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