Terpinen-4-ol and nystatin co-loaded precursor of liquid crystalline system for topical treatment of oral candidiasis

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorFrancisconi, Renata Serignoli [UNESP]-
Autor(es): dc.creatorMaquera-Huacho, Patricia Milagros [UNESP]-
Autor(es): dc.creatorTonon, Caroline Coradi [UNESP]-
Autor(es): dc.creatorCalixto, Giovana Maria Fioramonti [UNESP]-
Autor(es): dc.creatorde Cássia Orlandi Sardi, Janaína-
Autor(es): dc.creatorChorilli, Marlus [UNESP]-
Autor(es): dc.creatorSpolidorio, Denise Madalena Palomari [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:31:52Z-
Data de disponibilização: dc.date.available2022-02-22T00:31:52Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-020-70085-z-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200836-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200836-
Descrição: dc.descriptionThis study was performed to develop a liquid crystalline system (LCS) incorporated with terpinen-4-ol and nystatin to evaluate its antifungal, antibiofilm, and synergistic/modulatory activity against Candida albicans. The LCS was composed of a dispersion containing 40% propoxylated and ethoxylated cetyl alcohol, 40% oleic acid, and 0.5% chitosan dispersion. According to analysis by polarized light microscopy, rheology, and mucoadhesion studies, the incorporation of 100% artificial saliva increased the pseudoplasticity, consistency index, viscosity, and mucoadhesion of the formulation. The minimum inhibitory concentration, minimum fungicidal concentration, and rate of biofilm development were used to evaluate antifungal activity; the LCS containing terpinen-4-ol and nystatin effectively inhibited C. albicans growth at a lower concentration, displaying a synergistic action. Therefore, LCS incorporated with terpinen-4-ol and nystatin is a promising alternative for preventing and treating infections and shows potential for the development of therapeutic strategies against candidiasis.-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry of Araraquara Universidade Estadual Paulista UNESP-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical of Araraquara UNESP-
Descrição: dc.descriptionDepartment of Physiological Sciences School of Dentistry of Piracicaba UNICAMP-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry of Araraquara Universidade Estadual Paulista UNESP-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical of Araraquara UNESP-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Título: dc.titleTerpinen-4-ol and nystatin co-loaded precursor of liquid crystalline system for topical treatment of oral candidiasis-
Tipo de arquivo: dc.typelivro digital-
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