Characterization of the vaginal microbiome in women of reproductive age from 5 Regions in Brazil

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Federal do Paraná (UFPR)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorMcGill University-
Autor(es): dc.contributorUniversity of Maryland School of Medicine-
Autor(es): dc.contributorUniversidade Federal da Paraíba (UFPB)-
Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.contributorState University of Pará (UEPA)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorMarconi, Camila [UNESP]-
Autor(es): dc.creatorEl-Zein, Mariam-
Autor(es): dc.creatorRavel, Jacques-
Autor(es): dc.creatorMa, Bing-
Autor(es): dc.creatorLima, Moises D.-
Autor(es): dc.creatorCarvalho, Newton Sergio-
Autor(es): dc.creatorAlves, Rosane R F.-
Autor(es): dc.creatorParada, Cristina M G L. [UNESP]-
Autor(es): dc.creatorLeite, Sandra H M.-
Autor(es): dc.creatorGiraldo, Paulo C.-
Autor(es): dc.creatorGonçalves, Ana K.-
Autor(es): dc.creatorFranco, Eduardo L.-
Autor(es): dc.creatorSilva, Marcia G. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:31:46Z-
Data de disponibilização: dc.date.available2022-02-22T00:31:46Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1097/OLQ.0000000000001204-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200809-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200809-
Descrição: dc.descriptionBackground Composition of the vaginal microbiome is strongly related to a woman's reproductive health and risk of sexually transmitted infections. Ethnoracial, behavioral, and environmental factors can influence microbiome. The Brazilian population is unique in terms of miscegenation of ethnic groups and behavioral characteristics across different regions. We aimed to characterize the vaginal microbiome of women from 5 geographical regions of Brazil. Methods We sequenced V3-V4 regions of 16S rRNA gene in vaginal samples of 609 reproductive-aged women. We performed logistic regression analyses to estimate odds ratios (OR) and 95% confidence intervals (CI) for the association between sociodemographic and behavioral factors with Lactobacillus-depleted microbiome (community state type [CST] IV). Results Vaginal samples were grouped into 5 CST: CST I (L. crispatus predominant, 30.5%), CST II (L. gasseri predominant, 4.4%), CST III (Lactobacillus iners predominant, 36.5%), CST IV (Lactobacillus-depleted, 27.4%), and CST V (L. jensenii predominant, 1.2%). Several factors were independently associated with CST IV, such as smoking (OR, 1.80; 95% CI, 1.02-3.18), number of partners (OR, 2.11; 95% CI, 1.20-3.70), and vaginal douching (OR, 2.24; 95% CI, 1.34-3.74). A protective effect was observed for milk/dairy intake (OR, 0.47; 95% CI, 0.27-0.82) and sitz bathing (OR, 0.43; 95% CI, 0.19-0.98). Conclusions Nearly two thirds of Brazilian women may be at an increased risk for adverse outcomes associated with a vaginal microbiota characterized by the depletion of Lactobacillus or dominance by L. iners, whose protective role has been widely questioned. Several factors related to sexual behavior and intimate hygiene were associated with CST IV.-
Descrição: dc.descriptionDepartment of Basic Pathology Federal University of Paraná (UFPR)-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School Sao Paulo State University (UNESP)-
Descrição: dc.descriptionDivision of Cancer Epidemiology McGill University-
Descrição: dc.descriptionInstitute of Genomic Science University of Maryland School of Medicine-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Federal University of Paraíba (UFPB)-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Federal University of Paraná (UFPR)-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Federal University of Goiás (UFG)-
Descrição: dc.descriptionDepartment of Nursing Botucatu Medical School Sao Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics State University of Pará (UEPA)-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Faculty of Medicine State University of Campinas (UNICAMP)-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Faculty of Medicine Federal University of Rio Grande Do Norte (UFPR)-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School Sao Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Nursing Botucatu Medical School Sao Paulo State University (UNESP)-
Formato: dc.format562-569-
Idioma: dc.languageen-
Relação: dc.relationSexually Transmitted Diseases-
???dc.source???: dc.sourceScopus-
Título: dc.titleCharacterization of the vaginal microbiome in women of reproductive age from 5 Regions in Brazil-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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