Moderate aerobic exercise-induced cytokines changes are disturbed in PPARα knockout mice

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual de Londrina (UEL)-
Autor(es): dc.creatorCabral-Santos, Carolina [UNESP]-
Autor(es): dc.creatorSilveira, Loreana Sanches-
Autor(es): dc.creatorChimin, Patricia-
Autor(es): dc.creatorRosa-Neto, José Cesar-
Autor(es): dc.creatorLira, Fábio Santos [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:31:40Z-
Data de disponibilização: dc.date.available2022-02-22T00:31:40Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.cyto.2020.155207-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200774-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200774-
Descrição: dc.descriptionThe nuclear transcriptional factor peroxisome proliferator activated receptor alpha (PPARα) plays a role in regulating genes involved in lipid metabolism, adipogenesis and inflammation. We aimed to assess the role of PPARα on exercise-mediated locally produced cytokines in adipose fat deposits and skeletal muscle. C57BL/6 (WT) and PPARα knockout (PPARα−/−) mice were examined. Each genotype was randomly subdivided into three groups: non-exercised, and euthanized 2 or 24 h after a moderate aerobic exercise session (run on a treadmill at 60% of maximum speed for 1 h). Fat content in gastrocnemius muscle and lipolytic activity in isolated adipose tissue from mesenteric (MEAT) and retroperitoneal (RPAT) adipose tissue were evaluated. In addition, Interleukin 6 (IL-6), interleukin 10 (IL-10), tumor necrosis factor α (TNF-α) and monocyte chemoattractant protein 1 (MCP-1) content were evaluated by ELISA. WT mice showed a maximum lipolysis rate, as well as higher IL-6, IL-10, and IL10/TNF-α ratio values 2 h post-exercise (RPAT only) compared with PPARα−/− mice. Taken together, our data suggests that PPARα knockout mice exhibited reduced lipolysis and anti-inflammatory response in adipose tissue following exercise, PPARα appears to play an important role in immunomodulatory and lipolysis signaling after acute moderate exercise.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Department of Physical Education Post-Graduation Program in Movement Sciences State University of São Paulo (UNESP) Presidente Prudente-
Descrição: dc.descriptionImmunometabolism Research Group Department of Cell and Developmental Biology University of São Paulo-
Descrição: dc.descriptionUniversidade Estadual de Londrina Centro de Educação Física e Desportos Departamento de Fundamentos da Educação Física-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Department of Physical Education Post-Graduation Program in Movement Sciences State University of São Paulo (UNESP) Presidente Prudente-
Descrição: dc.descriptionFAPESP: 2014/01246-6-
Descrição: dc.descriptionFAPESP: 2015/26148-0-
Descrição: dc.descriptionFAPESP: 2018/17648-7-
Idioma: dc.languageen-
Relação: dc.relationCytokine-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCytokines-
Palavras-chave: dc.subjectInflammatory response-
Palavras-chave: dc.subjectLipid metabolism-
Palavras-chave: dc.subjectPeroxisome proliferator activated receptor-
Título: dc.titleModerate aerobic exercise-induced cytokines changes are disturbed in PPARα knockout mice-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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