Strength Training Modulates Prostate of Wistar Rats Submitted to High-Fat Diet

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Guelph-
Autor(es): dc.creatorVeras, Allice Santos Cruz [UNESP]-
Autor(es): dc.creatorde Freitas, Marcelo Conrado [UNESP]-
Autor(es): dc.creatorThorpe, Hayley Hope Allyssa-
Autor(es): dc.creatorSeraphim, Patrícia Monteiro [UNESP]-
Autor(es): dc.creatorTeixeira, Giovana Rampazzo [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:31:26Z-
Data de disponibilização: dc.date.available2022-02-22T00:31:26Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s43032-020-00238-y-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200693-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200693-
Descrição: dc.descriptionOur aim is to evaluate the effects of high-fat diet and strength training on ventral prostate health through investigations of rat prostate histology, endocrine modulation, and the expression of proliferative and apoptotic marker, including androgen receptors (AR), glucocorticoid receptors (GR), B-cell lymphoma 2 (Bcl-2), Bcl-2 associated X protein (BAX), Fas cell surface death receptor (Fas/CD95/Apo-1), and Nuclear Factor Kappa-B (NF-κB). Eighty Wistar rats were into one of four subgroups: control (CT), strength training (ST), high-fat diet consumption (HF), and high-fat diet consumption with strength training (HFT). Animals then underwent strength training and/or high-fat diet consumption for 8 or 12 weeks, after which animals were euthanized and markers of prostatic health were evaluated histologically and through immunolabeling. Our results indicate that physical strength training reduced the expression of the prostate cell proliferation marker Bcl-2 while increasing expression of the pro-apoptotic marker BAX, as well as increasing expression of AR and GR relevant in the Bcl-2 pathway. We conclude that a high-fat diet can alter hormone receptor levels and cell-cycle protein expression, thereby modifying prostatic homeostasis, and that strength training was able to reduce prostate damage induced by high-fat diet consumption.-
Descrição: dc.descriptionPostgraduate Program in Movement Sciences Sao Paulo State University - UNESP, Campus of Presidente Prudente-
Descrição: dc.descriptionDepartment of Physical Education Faculty of Technology and Sciences State University of São Paulo UNESP, Presidente Prudente Campus, Rua Roberto Simonsen, 305-
Descrição: dc.descriptionDepartment of Physiotherapy Faculty of Technology and Sciences UNESP, Campus of Presidente Prudente-
Descrição: dc.descriptionDepartment of Biomedical Sciences Ontario Veterinary College University of Guelph-
Descrição: dc.descriptionPostgraduate Program in Movement Sciences Sao Paulo State University - UNESP, Campus of Presidente Prudente-
Descrição: dc.descriptionDepartment of Physical Education Faculty of Technology and Sciences State University of São Paulo UNESP, Presidente Prudente Campus, Rua Roberto Simonsen, 305-
Descrição: dc.descriptionDepartment of Physiotherapy Faculty of Technology and Sciences UNESP, Campus of Presidente Prudente-
Idioma: dc.languageen-
Relação: dc.relationReproductive Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectApoptosis pathway-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectPhysical exercise-
Palavras-chave: dc.subjectProstate health-
Título: dc.titleStrength Training Modulates Prostate of Wistar Rats Submitted to High-Fat Diet-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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