Genetic instability assessed by telomere length and micronucleus in physicians exposed to anesthetics

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorBraz, Mariana G. [UNESP]-
Autor(es): dc.creatorSilva, Mariane A. P. [UNESP]-
Autor(es): dc.creatorFigueiredo, Drielle B. S. [UNESP]-
Autor(es): dc.creatorAun, Aline G. [UNESP]-
Autor(es): dc.creatorMarques, Lais S. K. [UNESP]-
Autor(es): dc.creatorLara, Juliana R. [UNESP]-
Autor(es): dc.creatorBraz, Leandro G. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:31:24Z-
Data de disponibilização: dc.date.available2022-02-22T00:31:24Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/em.22380-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200683-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200683-
Descrição: dc.descriptionThis study evaluated both telomere length (TL) and micronucleus (MN) as indicators of genome instability in 40 anesthesiologists occupationally exposed to anesthetics and in 40 physicians without occupational exposure to anesthetics who were matched by age, sex, and lifestyle. Blood and buccal samples were collected from both groups at the same period. Anesthetic exposure assessment was performed. The studied groups were assessed regarding relative TL by quantitative polymerase chain reaction and MN by buccal MN assay. Mean trace concentrations of anesthetics were below two parts per million. No significant differences between groups were found for both biomarkers. However, MN frequency was slightly increased (1.9-fold; p =.094) in the exposed group compared to the control group and in the exposed males (2.4-fold; p =.090) compared to unexposed males. TL and age showed a significant negative correlation. Anesthetic occupational exposure below recommended levels is not associated with changes in TL and MN in anesthesiologists.-
Descrição: dc.descriptionGENOTOX Laboratory Department of Anesthesiology Botucatu Medical School São Paulo State University – UNESP-
Descrição: dc.descriptionGENOTOX Laboratory Department of Anesthesiology Botucatu Medical School São Paulo State University – UNESP-
Idioma: dc.languageen-
Relação: dc.relationEnvironmental and Molecular Mutagenesis-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectanesthesiologists-
Palavras-chave: dc.subjectinhalation anesthetics-
Palavras-chave: dc.subjectmicronuclei-
Palavras-chave: dc.subjectoccupational exposure-
Palavras-chave: dc.subjecttelomere-
Título: dc.titleGenetic instability assessed by telomere length and micronucleus in physicians exposed to anesthetics-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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