Chick embryo chorioallantoic membrane as a suitable in vivo model to evaluate drug delivery systems for cancer treatment: A review

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Minho-
Autor(es): dc.contributorICVS/3B's-PT Government Associate Laboratory-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorVictorelli, Francesca Damiani [UNESP]-
Autor(es): dc.creatorCardoso, Valéria Maria de Oliveira [UNESP]-
Autor(es): dc.creatorFerreira, Natália Noronha [UNESP]-
Autor(es): dc.creatorCalixto, Giovana Maria Fioramonti [UNESP]-
Autor(es): dc.creatorFontana, Carla Raquel [UNESP]-
Autor(es): dc.creatorBaltazar, Fátima-
Autor(es): dc.creatorGremião, Maria Palmira Daflon [UNESP]-
Autor(es): dc.creatorChorilli, Marlus [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:31:23Z-
Data de disponibilização: dc.date.available2022-02-22T00:31:23Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ejpb.2020.06.010-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200675-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200675-
Descrição: dc.descriptionCancer represents a significant public health problem. More than 18.1 million people are annually diagnosed with cancer and 9.6 million die mainly due to metastatic disease. Chemotherapy has been one of the main cancer treatment modalities; however, most of the chemotherapeutic agents are non-specific, exhibiting several toxic side effects, which compromises the patient's quality of life. Therefore, it is necessary to search for new therapeutic alternatives, using for example, drug delivery systems (DDS) to target cancer cells, increasing the selectivity of chemotherapeutic drugs. This approach is promising; however, it is crucial to evaluate the biological performance of the systems. Although mammalian models continue to be explored for clinical applications, they are time-consuming and very restrictive from the ethical and legal perspectives. Hence, the chick embryo chorioallantoic membrane (CAM) has been shown to be a suitable in vivo model since it allows a more appropriate model for the study of drugs and/or DDS performance than in vitro tests. Thereby, this article revises the recent advances of DDS for cancer therapy, evaluating the feasibility of the CAM model.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionUNESP São Paulo State University School of Pharmaceutical Sciences Department of Drugs and Medicines-
Descrição: dc.descriptionUNESP São Paulo State University School of Pharmaceutical Sciences Department of Clinical Analysis-
Descrição: dc.descriptionLife and Health Sciences Research Institute (ICVS) School of Medicine University of Minho-
Descrição: dc.descriptionICVS/3B's-PT Government Associate Laboratory-
Descrição: dc.descriptionUNICAMP University of Campinas Piracicaba Dental School Department of Biosciences-
Descrição: dc.descriptionUNESP São Paulo State University School of Pharmaceutical Sciences Department of Drugs and Medicines-
Descrição: dc.descriptionUNESP São Paulo State University School of Pharmaceutical Sciences Department of Clinical Analysis-
Descrição: dc.descriptionFAPESP: #2013/01565-1-
Descrição: dc.descriptionFAPESP: #2015/21412-0-
Descrição: dc.descriptionFAPESP: #2016/06337-5, #2019/07245-5-
Descrição: dc.descriptionFAPESP: #2016/09671-3-
Descrição: dc.descriptionFAPESP: #2017/10016-2-
Descrição: dc.descriptionFAPESP: #2017/23357-2-
Descrição: dc.descriptionFAPESP: #2018/04546-1-
Formato: dc.format273-284-
Idioma: dc.languageen-
Relação: dc.relationEuropean Journal of Pharmaceutics and Biopharmaceutics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAngiogenesis-
Palavras-chave: dc.subjectAnti-angiogenic-
Palavras-chave: dc.subjectCAM model-
Palavras-chave: dc.subjectCancer-
Palavras-chave: dc.subjectChicken embryos-
Palavras-chave: dc.subjectDrug delivery systems-
Título: dc.titleChick embryo chorioallantoic membrane as a suitable in vivo model to evaluate drug delivery systems for cancer treatment: A review-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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