Heat Shock Protein 60 Antibodies Are Associated With a Risk Factor for Cardiovascular Disease in Bedridden Elderly Patients

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Autor(es): dc.contributorOeste Paulista University – UNOESTE-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorFederal University of Triangulo Mineiro (UFTM)-
Autor(es): dc.creatorde Lima Filho, Jonas Bernardes-
Autor(es): dc.creatorFreire, Letícia-
Autor(es): dc.creatorNahas, Eliana Aguiar Petri [UNESP]-
Autor(es): dc.creatorOrsatti, Fábio Lera-
Autor(es): dc.creatorOrsatti, Claudio Lera-
Data de aceite: dc.date.accessioned2022-02-22T00:31:22Z-
Data de disponibilização: dc.date.available2022-02-22T00:31:22Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-06-12-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fmolb.2020.00103-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200667-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200667-
Descrição: dc.descriptionFrailty, in elderly people, represents multiple deficiencies in different organs and is characterized by decreased physiological reserves and greater vulnerability to stressors. Bedridden elderly, with cardiovascular disease (CVD), have a worse prognosis than non-bedridden patients. Heat-shock proteins (HSPs) are molecular chaperones that under physiological conditions facilitate the transport, folding and assembly of proteins. Serum HSP 60-kDa concentrations and their antibodies are increased, in response to non-physiological conditions, suggesting the involvement of HSPs and their antibodies in the development of CVD. The aim of this work was to evaluate heat shock protein 60 and anti-HSP60 antibody levels, associated with a risk factor for cardiovascular disease, in bedridden elderly patients. Clinical, analytical and cross-sectional analyses were performed with 57 elderly (>65 years). HSP60 and anti-HSP60 plasma levels were measured by ELISA. Bivariate analysis using a linear regression model adjusted for risk factors used Framingham Score. Among the 57 elderly, with an average age of 69.89 years, 39% are bedridden; 26% with pre-existing cardiovascular disease and 44% are dyslipidemic. The relationship of risk factors in the Framingham Score was positive for the anti-HSP60 antibody (p = 0.042) measurement. Our data show a positive correlation among the elevation of the Framingham score and the profile of anti-HSP60 antibodies. These results suggest a greater immune activation that is associated with cardiovascular risk and bedridden fragility.-
Descrição: dc.descriptionDepartment of Health Science Oeste Paulista University – UNOESTE-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Botucatu Medical School Paulista State University (UNESP)-
Descrição: dc.descriptionDepartment of Sport Sciences Health Science Institute Federal University of Triangulo Mineiro (UFTM)-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Botucatu Medical School Paulista State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Molecular Biosciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectanti-HSP60 antibody-
Palavras-chave: dc.subjectbedridden elderly-
Palavras-chave: dc.subjectcardiovascular disease-
Palavras-chave: dc.subjectHSP60-
Palavras-chave: dc.subjectrisk factors-
Título: dc.titleHeat Shock Protein 60 Antibodies Are Associated With a Risk Factor for Cardiovascular Disease in Bedridden Elderly Patients-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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