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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Oeste Paulista University – UNOESTE | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Federal University of Triangulo Mineiro (UFTM) | - |
Autor(es): dc.creator | de Lima Filho, Jonas Bernardes | - |
Autor(es): dc.creator | Freire, Letícia | - |
Autor(es): dc.creator | Nahas, Eliana Aguiar Petri [UNESP] | - |
Autor(es): dc.creator | Orsatti, Fábio Lera | - |
Autor(es): dc.creator | Orsatti, Claudio Lera | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:31:22Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:31:22Z | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-06-12 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.3389/fmolb.2020.00103 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/200667 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/200667 | - |
Descrição: dc.description | Frailty, in elderly people, represents multiple deficiencies in different organs and is characterized by decreased physiological reserves and greater vulnerability to stressors. Bedridden elderly, with cardiovascular disease (CVD), have a worse prognosis than non-bedridden patients. Heat-shock proteins (HSPs) are molecular chaperones that under physiological conditions facilitate the transport, folding and assembly of proteins. Serum HSP 60-kDa concentrations and their antibodies are increased, in response to non-physiological conditions, suggesting the involvement of HSPs and their antibodies in the development of CVD. The aim of this work was to evaluate heat shock protein 60 and anti-HSP60 antibody levels, associated with a risk factor for cardiovascular disease, in bedridden elderly patients. Clinical, analytical and cross-sectional analyses were performed with 57 elderly (>65 years). HSP60 and anti-HSP60 plasma levels were measured by ELISA. Bivariate analysis using a linear regression model adjusted for risk factors used Framingham Score. Among the 57 elderly, with an average age of 69.89 years, 39% are bedridden; 26% with pre-existing cardiovascular disease and 44% are dyslipidemic. The relationship of risk factors in the Framingham Score was positive for the anti-HSP60 antibody (p = 0.042) measurement. Our data show a positive correlation among the elevation of the Framingham score and the profile of anti-HSP60 antibodies. These results suggest a greater immune activation that is associated with cardiovascular risk and bedridden fragility. | - |
Descrição: dc.description | Department of Health Science Oeste Paulista University – UNOESTE | - |
Descrição: dc.description | Department of Gynecology and Obstetrics Botucatu Medical School Paulista State University (UNESP) | - |
Descrição: dc.description | Department of Sport Sciences Health Science Institute Federal University of Triangulo Mineiro (UFTM) | - |
Descrição: dc.description | Department of Gynecology and Obstetrics Botucatu Medical School Paulista State University (UNESP) | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Frontiers in Molecular Biosciences | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | anti-HSP60 antibody | - |
Palavras-chave: dc.subject | bedridden elderly | - |
Palavras-chave: dc.subject | cardiovascular disease | - |
Palavras-chave: dc.subject | HSP60 | - |
Palavras-chave: dc.subject | risk factors | - |
Título: dc.title | Heat Shock Protein 60 Antibodies Are Associated With a Risk Factor for Cardiovascular Disease in Bedridden Elderly Patients | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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