Copper(II) biocompatible coordination solids as potential platforms for diclofenac delivery systems

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorAlves, Renata Carolina [UNESP]-
Autor(es): dc.creatorLucena, Guilherme Nunes [UNESP]-
Autor(es): dc.creatorde Farias, Renan Lira [UNESP]-
Autor(es): dc.creatorda Silva, Patrícia Bento [UNESP]-
Autor(es): dc.creatorda Silva, Isabel Cristiane [UNESP]-
Autor(es): dc.creatorPavan, Fernando Rogério [UNESP]-
Autor(es): dc.creatorChorilli, Marlus [UNESP]-
Autor(es): dc.creatorda Costa Ferreira, Ana Maria-
Autor(es): dc.creatorGalvão Frem, Regina Célia [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:31:11Z-
Data de disponibilização: dc.date.available2022-02-22T00:31:11Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jssc.2020.121479-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200609-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200609-
Descrição: dc.descriptionThis study deals a new copper(II)-based cluster-organic framework, CUBA, targeted a matrix for diclofenac sodium delivery. CUBA was prepared by solvothermal reaction and characterized by several techniques. FEG-SEM data revealed presence of random porous over CUBA surface. BET equation fitting N2-adsorption isotherm showed a surface area and pore volume amount to ca. 55 ​m2 ​g-1 and 0.49 ​cm3 ​g-1, respectively. In vitro assays showed non-cytotoxic activity for CUBA in MRC-5 ​cell line. A microporous copper(II)-based metal-organic framework, herein labelled as BioMOF-Cu, was used as a comparison in drug load-releasing tests. CUBA exhibited encapsulation efficiency of 29.47, 36.74 and 60.72% at 2, 4 and 7 days, respectively, BioMOF-Cu showed 84.68% at 4 days. In PBS solution CUBA ranged at 13-18% of total drug-releasing at 72 ​h and BioMOF-Cu afforded 21% at 48 ​h. In vivo evaluation of the anti-inflammatory effects, CUBA and BioMOF-Cu decreased the paw edema when compared to the negative group.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Chemistry-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences Department of Drugs and Medicines-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences Department of Biological Sciences-
Descrição: dc.descriptionUniversity of São Paulo (USP) Institute of Chemistry Department of Fundamental Chemistry-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Chemistry-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences Department of Drugs and Medicines-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences Department of Biological Sciences-
Descrição: dc.descriptionCAPES: 001-
Idioma: dc.languageen-
Relação: dc.relationJournal of Solid State Chemistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCluster-organic framework-
Palavras-chave: dc.subjectDiclofenac sodium-
Palavras-chave: dc.subjectDrug delivery-
Palavras-chave: dc.subjectIn vivo evaluation-
Título: dc.titleCopper(II) biocompatible coordination solids as potential platforms for diclofenac delivery systems-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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