Should mast cells be considered therapeutic targets in multiple sclerosis?

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorPinke, Karen [UNESP]-
Autor(es): dc.creatorZorzella-Pezavento, Sofia [UNESP]-
Autor(es): dc.creatorLara, Vanessa-
Autor(es): dc.creatorSartori, Alexandrina [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:31:10Z-
Data de disponibilização: dc.date.available2022-02-22T00:31:10Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.4103/1673-5374.282238-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200604-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200604-
Descrição: dc.descriptionMast cells are immune cells of the myeloid lineage that are found throughout the body, including the central nervous system. They perform many functions associated with innate and specific immunity, angiogenesis, and vascular homeostasis. Moreover, they have been implicated in a series of pathologies (e.g., hypersensitivity reactions, tumors, and inflammatory disorders). In this review, we propose that this cell could be a relevant therapeutic target in multiple sclerosis, which is a central nervous system degenerative disease. To support this proposition, we describe the general biological properties of mast cells, their contribution to innate and specific immunity, and the participation of mast cells in the various stages of multiple sclerosis and experimental autoimmune encephalomyelitis development. The final part of this review is dedicated to an overview of the available mast cells immunomodulatory drugs and their activity on multiple sclerosis and experimental autoimmune encephalomyelitis, including our own experience related to the effect of ketotifen fumarate on experimental autoimmune encephalomyelitis evolution.-
Descrição: dc.descriptionInstitute of Biosciences Department of Microbiology and Immunology São Paulo State University (UNESP)-
Descrição: dc.descriptionBauru School of Dentistry Department of Surgery Stomatology Pathology and Radiology University of São Paulo-
Descrição: dc.descriptionInstitute of Biosciences Department of Microbiology and Immunology São Paulo State University (UNESP)-
Formato: dc.format1995-2007-
Idioma: dc.languageen-
Relação: dc.relationNeural Regeneration Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcentral nervous system-
Palavras-chave: dc.subjectdegenerative disease-
Palavras-chave: dc.subjectexperimental autoimmune encephalomyelitis-
Palavras-chave: dc.subjectimmunity-
Palavras-chave: dc.subjectimmunomodulatory drugs-
Palavras-chave: dc.subjectinflammatory disease-
Palavras-chave: dc.subjectketotifen fumarate-
Palavras-chave: dc.subjectmast cells-
Palavras-chave: dc.subjectmultiple sclerosis-
Palavras-chave: dc.subjecttherapeutic target-
Título: dc.titleShould mast cells be considered therapeutic targets in multiple sclerosis?-
Aparece nas coleções:Repositório Institucional - Unesp

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