Cytogenotoxic evaluation of the acetonitrile extract, citrinin and dicitrinin-A from Penicillium citrinum

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Piauí–IFPI-
Autor(es): dc.contributorScience and Technology of Maranhão–IFMA-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorFederal University of Piauí-
Autor(es): dc.contributorFederal University of Maranhão-
Autor(es): dc.contributorTon Duc Thang University-
Autor(es): dc.contributorCoventry University-
Autor(es): dc.creatorde Oliveira Filho, José Williams Gomes-
Autor(es): dc.creatorAndrade, Teresinha de Jesus Aguiar dos Santos-
Autor(es): dc.creatorde Lima, Rosália Maria Tôrres-
Autor(es): dc.creatorSilva, Dulce Helena Siqueira [UNESP]-
Autor(es): dc.creatordos Reis, Antonielly Campinho-
Autor(es): dc.creatorSantos, José Victor de Oliveira-
Autor(es): dc.creatorde Meneses, Ag-Anne Pereira Melo-
Autor(es): dc.creatorde Carvalho, Ricardo Melo-
Autor(es): dc.creatorda Mata, Ana Maria Oliveira-
Autor(es): dc.creatorde Alencar, Marcus Vinícius Oliveira Barros-
Autor(es): dc.creatorDias, Ana Carolina Soares-
Autor(es): dc.creatorda Silva, Felipe Cavalcanti Carneiro-
Autor(es): dc.creatorIslam, Muhammad Torequl-
Autor(es): dc.creatorClark, Cain C. T.-
Autor(es): dc.creatorSousa, João Marcelo de Castro e-
Autor(es): dc.creatorMelo-Cavalcante, Ana Amélia de Carvalho-
Data de aceite: dc.date.accessioned2022-02-22T00:31:06Z-
Data de disponibilização: dc.date.available2022-02-22T00:31:06Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/01480545.2020.1769642-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200574-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200574-
Descrição: dc.descriptionEndophytic fungi are promising sources of bioactive substances; however, their secondary metabolites are toxic to plants, animals, and humans. This study aimed toevaluate the toxic, cytotoxic, mutagenic and oxidant/antioxidant activities of acetonitrile extract (AEPc), citrinin (CIT) and dicitrinin-A (DIC-A) of Penicillium citrinum. For this, the test substances at 0.5; 1.0; 1.5 and 2 μg/mLwere exposed for 24 and 48 h in Artemia salina, and 48 h in Allium cepa test systems. The oxidant/antioxidant test was evaluated in pre-, co- and post-treatment with the stressor hydrogen peroxide (H2O2) in Saccharomyces cerevisiae. The results suggest that the AEPc, CIT and DIC-A at 0.5; 1.0; 1.5 and 2 μg/mL showed toxicity in A. saline, with LC50 (24 h) of 2.03 μg/mL, 1.71 μg/mL and 2.29 μg/mL, and LC50 (48 h) of 0.51 μg/mL, 0.54 μg/mL and 0.54 μg/mL, respectively.In A. cepa, the test substances also exerted cytotoxic and mutagenic effects. The AEPc, CIT and DIC-A at lower concentrations modulated the damage induced by H2O2 in the proficient and mutant strains of S. cerevisiae for cytoplasmic and mitochondrial superoxide dismutase. Moreover, the AEPc at 2 μg/mL and CIT at the two highest concentrations did not affect the H2O2-induced DNA damage in the test strains. In conclusion, AEPc, CIT and DIC-A of P. citrinum may exert their toxic, cytotoxic and mutagenic effects in the test systems possibly through oxidative stress induction pathway.-
Descrição: dc.descriptionNortheast Biotechnology Network (RENORBIO) Postgraduate Program in Biotechnology Federal University of Piauí–IFPI-
Descrição: dc.descriptionNucleus of Applied Research to Sciences (NIAC) Federal Institute of Education Science and Technology of Maranhão–IFMA-
Descrição: dc.descriptionNucleus of Bioassays Biosynthesis and Ecophysiology of Natural Products (NuBBE) Department of Organic Chemistry Institute of Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionLaboratory of Research in Toxicological Genetics–LAPGENIC Federal University of Piauí-
Descrição: dc.descriptionLaboratory of Genetics and Molecular Biology Federal University of Maranhão-
Descrição: dc.descriptionPostgraduate Program in Pharmaceutical Sciences Federal University of Piauí-
Descrição: dc.descriptionLaboratory of Theoretical and Computational Biophysics Ton Duc Thang University-
Descrição: dc.descriptionFaculty of Pharmacy Ton Duc Thang University-
Descrição: dc.descriptionCentre for Sport Exercise and Life Sciences Coventry University-
Descrição: dc.descriptionNucleus of Bioassays Biosynthesis and Ecophysiology of Natural Products (NuBBE) Department of Organic Chemistry Institute of Chemistry São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationDrug and Chemical Toxicology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcytotoxicity-
Palavras-chave: dc.subjectEndophytic fungi-
Palavras-chave: dc.subjectgenotoxicity-
Palavras-chave: dc.subjectmutagenicity-
Palavras-chave: dc.subjectmycotoxins-
Palavras-chave: dc.subjectPenicillium citrinum-
Título: dc.titleCytogenotoxic evaluation of the acetonitrile extract, citrinin and dicitrinin-A from Penicillium citrinum-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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