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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Federal University of Piauí–IFPI | - |
Autor(es): dc.contributor | Science and Technology of Maranhão–IFMA | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Federal University of Piauí | - |
Autor(es): dc.contributor | Federal University of Maranhão | - |
Autor(es): dc.contributor | Ton Duc Thang University | - |
Autor(es): dc.contributor | Coventry University | - |
Autor(es): dc.creator | de Oliveira Filho, José Williams Gomes | - |
Autor(es): dc.creator | Andrade, Teresinha de Jesus Aguiar dos Santos | - |
Autor(es): dc.creator | de Lima, Rosália Maria Tôrres | - |
Autor(es): dc.creator | Silva, Dulce Helena Siqueira [UNESP] | - |
Autor(es): dc.creator | dos Reis, Antonielly Campinho | - |
Autor(es): dc.creator | Santos, José Victor de Oliveira | - |
Autor(es): dc.creator | de Meneses, Ag-Anne Pereira Melo | - |
Autor(es): dc.creator | de Carvalho, Ricardo Melo | - |
Autor(es): dc.creator | da Mata, Ana Maria Oliveira | - |
Autor(es): dc.creator | de Alencar, Marcus Vinícius Oliveira Barros | - |
Autor(es): dc.creator | Dias, Ana Carolina Soares | - |
Autor(es): dc.creator | da Silva, Felipe Cavalcanti Carneiro | - |
Autor(es): dc.creator | Islam, Muhammad Torequl | - |
Autor(es): dc.creator | Clark, Cain C. T. | - |
Autor(es): dc.creator | Sousa, João Marcelo de Castro e | - |
Autor(es): dc.creator | Melo-Cavalcante, Ana Amélia de Carvalho | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:31:06Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:31:06Z | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2019-12-31 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1080/01480545.2020.1769642 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/200574 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/200574 | - |
Descrição: dc.description | Endophytic fungi are promising sources of bioactive substances; however, their secondary metabolites are toxic to plants, animals, and humans. This study aimed toevaluate the toxic, cytotoxic, mutagenic and oxidant/antioxidant activities of acetonitrile extract (AEPc), citrinin (CIT) and dicitrinin-A (DIC-A) of Penicillium citrinum. For this, the test substances at 0.5; 1.0; 1.5 and 2 μg/mLwere exposed for 24 and 48 h in Artemia salina, and 48 h in Allium cepa test systems. The oxidant/antioxidant test was evaluated in pre-, co- and post-treatment with the stressor hydrogen peroxide (H2O2) in Saccharomyces cerevisiae. The results suggest that the AEPc, CIT and DIC-A at 0.5; 1.0; 1.5 and 2 μg/mL showed toxicity in A. saline, with LC50 (24 h) of 2.03 μg/mL, 1.71 μg/mL and 2.29 μg/mL, and LC50 (48 h) of 0.51 μg/mL, 0.54 μg/mL and 0.54 μg/mL, respectively.In A. cepa, the test substances also exerted cytotoxic and mutagenic effects. The AEPc, CIT and DIC-A at lower concentrations modulated the damage induced by H2O2 in the proficient and mutant strains of S. cerevisiae for cytoplasmic and mitochondrial superoxide dismutase. Moreover, the AEPc at 2 μg/mL and CIT at the two highest concentrations did not affect the H2O2-induced DNA damage in the test strains. In conclusion, AEPc, CIT and DIC-A of P. citrinum may exert their toxic, cytotoxic and mutagenic effects in the test systems possibly through oxidative stress induction pathway. | - |
Descrição: dc.description | Northeast Biotechnology Network (RENORBIO) Postgraduate Program in Biotechnology Federal University of Piauí–IFPI | - |
Descrição: dc.description | Nucleus of Applied Research to Sciences (NIAC) Federal Institute of Education Science and Technology of Maranhão–IFMA | - |
Descrição: dc.description | Nucleus of Bioassays Biosynthesis and Ecophysiology of Natural Products (NuBBE) Department of Organic Chemistry Institute of Chemistry São Paulo State University (UNESP) | - |
Descrição: dc.description | Laboratory of Research in Toxicological Genetics–LAPGENIC Federal University of Piauí | - |
Descrição: dc.description | Laboratory of Genetics and Molecular Biology Federal University of Maranhão | - |
Descrição: dc.description | Postgraduate Program in Pharmaceutical Sciences Federal University of Piauí | - |
Descrição: dc.description | Laboratory of Theoretical and Computational Biophysics Ton Duc Thang University | - |
Descrição: dc.description | Faculty of Pharmacy Ton Duc Thang University | - |
Descrição: dc.description | Centre for Sport Exercise and Life Sciences Coventry University | - |
Descrição: dc.description | Nucleus of Bioassays Biosynthesis and Ecophysiology of Natural Products (NuBBE) Department of Organic Chemistry Institute of Chemistry São Paulo State University (UNESP) | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Drug and Chemical Toxicology | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | cytotoxicity | - |
Palavras-chave: dc.subject | Endophytic fungi | - |
Palavras-chave: dc.subject | genotoxicity | - |
Palavras-chave: dc.subject | mutagenicity | - |
Palavras-chave: dc.subject | mycotoxins | - |
Palavras-chave: dc.subject | Penicillium citrinum | - |
Título: dc.title | Cytogenotoxic evaluation of the acetonitrile extract, citrinin and dicitrinin-A from Penicillium citrinum | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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