Comparative Evaluation of Bone Repair with Four Different Bone Substitutes in Critical Size Defects

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Sagrado Coracao-
Autor(es): dc.creatorGrossi-Oliveira, Gustavo [UNESP]-
Autor(es): dc.creatorFaverani, Leonardo P. [UNESP]-
Autor(es): dc.creatorMendes, Bruno Coelho [UNESP]-
Autor(es): dc.creatorBraga Polo, Tárik Ocon [UNESP]-
Autor(es): dc.creatorBatista Mendes, Gabriel Cury-
Autor(es): dc.creatorLima, Valthierre Nunes De [UNESP]-
Autor(es): dc.creatorRibeiro Júnior, Paulo Domingos-
Autor(es): dc.creatorOkamoto, Roberta [UNESP]-
Autor(es): dc.creatorMagro-Filho, Osvaldo [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:31:04Z-
Data de disponibilização: dc.date.available2022-02-22T00:31:04Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1155/2020/5182845-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200564-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200564-
Descrição: dc.descriptionThis study evaluated the osteoconductive potential of four biomaterials used to fill bone defects. For this, 24 male Albino rabbits were submitted to the creation of a bilateral 8 mm calvarial bone defect. The animals were divided into four groups - bovine hydroxyapatite, Bio-Oss® (BIO); Lumina-Bone Porous® (LBP); Bonefill® (BFL); and an alloplastic material, Clonos® (CLN) - and were euthanized at 14 and 40 days. The samples were subjected to histological and histometric analysis for newly formed bone area. Immunohistochemical analysis for Runt-related transcription factor 2 (Runx2), vascular endothelial growth factor (VEGF), and osteocalcin (OC) was performed. After statistical analysis, the CLN group showed greater new bone formation (NB) in both periods analyzed (p<0.05). At 14 days, the NB showed greater values in BIO in relation to LBP and BFL groups; however, after 40 days, the LBP group surpassed the results of BIO (p<0.001). The immunostaining showed a decrease in Runx2 intensity in BIO after 40 days, while it increased for LBP (p<0.05). The CLN showed increased OC compared to the other groups in both periods analyzed (p<0.05). Therefore, CLN showed the best osteoconductive behavior in critical defects in rabbit calvaria, and BFL showed the lowest osteoconductive property.-
Descrição: dc.descriptionOral and Maxillofacial Surgery Diagnostic and Surgery Aracatuba School of Dentistry Sao Paulo State University (UNESP)-
Descrição: dc.descriptionOral and Maxillofacial Surgery Department of Oral Surgery University of Sagrado Coracao-
Descrição: dc.descriptionHuman Anatomy Department of Basic Sciences Aracatuba School of Dentistry Sao Paulo State University (UNESP)-
Descrição: dc.descriptionOral and Maxillofacial Surgery Diagnostic and Surgery Aracatuba School of Dentistry Sao Paulo State University (UNESP)-
Descrição: dc.descriptionHuman Anatomy Department of Basic Sciences Aracatuba School of Dentistry Sao Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Biomaterials-
???dc.source???: dc.sourceScopus-
Título: dc.titleComparative Evaluation of Bone Repair with Four Different Bone Substitutes in Critical Size Defects-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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