Direct Analysis of Doping Agents in Raw Urine Using Hydrophobic Paper Spray Mass Spectrometry

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorOhio State University-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorRossini, Eduardo Luiz [UNESP]-
Autor(es): dc.creatorKulyk, Dmytro S.-
Autor(es): dc.creatorAnsu-Gyeabourh, Emelia-
Autor(es): dc.creatorSahraeian, Taghi-
Autor(es): dc.creatorPezza, Helena Redigolo [UNESP]-
Autor(es): dc.creatorBadu-Tawiah, Abraham K.-
Data de aceite: dc.date.accessioned2022-02-22T00:31:03Z-
Data de disponibilização: dc.date.available2022-02-22T00:31:03Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-06-03-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1021/jasms.0c00063-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200553-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200553-
Descrição: dc.descriptionIn this study, the direct analysis of doping agents in urine samples with no sample preparation by a modified paper spray mass spectrometry (PS-MS) methodology has been demonstrated for the first time. We have described a paper surface treatment with trichloromethylsilane using a gas-phase reaction to increase the ionization of target compounds. This approach was applied for the analysis of two classes of banned substances in urine samples: anabolic agents (trenbolone and clenbuterol) and diuretics (furosemide and hydrochlorothiazide). Under optimized conditions, the developed methods presented satisfactory repeatability, and an analysis of variance showed linearity without lack-of-fit. Highly sensitive detections as low as sub-nanogram per milliliter levels, which is below the minimum required performance levels proposed by the World Anti-Doping Agency, have been reached using the hydrophobic PS-MS analysis without any preconcentration and cleanup step.-
Descrição: dc.descriptionDepartment of Chemistry and Biochemistry Ohio State University, 100 West 18th Avenue-
Descrição: dc.descriptionInstitute of Chemistry Department of Analytical Chemistry São Paulo State University (UNESP), Rua Professor Francisco Degni 55 ,P.O. Box 355-
Descrição: dc.descriptionInstitute of Chemistry Department of Analytical Chemistry São Paulo State University (UNESP), Rua Professor Francisco Degni 55 ,P.O. Box 355-
Formato: dc.format1212-1222-
Idioma: dc.languageen-
Relação: dc.relationJournal of the American Society for Mass Spectrometry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectanabolic agent-
Palavras-chave: dc.subjectanalytical methods-
Palavras-chave: dc.subjectdiuretic-
Palavras-chave: dc.subjectdoping-
Palavras-chave: dc.subjectpaper modification-
Palavras-chave: dc.subjectpaper spray ionization-
Título: dc.titleDirect Analysis of Doping Agents in Raw Urine Using Hydrophobic Paper Spray Mass Spectrometry-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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