Highlighting the impact of chitosan on the development of gastroretentive drug delivery systems

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorSouza, Maurício Palmeira Chaves de [UNESP]-
Autor(es): dc.creatorSábio, Rafael Miguel [UNESP]-
Autor(es): dc.creatorRibeiro, Tais de Cassia [UNESP]-
Autor(es): dc.creatorSantos, Aline Martins dos [UNESP]-
Autor(es): dc.creatorMeneguin, Andréia Bagliotti [UNESP]-
Autor(es): dc.creatorChorilli, Marlus [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:30:56Z-
Data de disponibilização: dc.date.available2022-02-22T00:30:56Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-09-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ijbiomac.2020.05.104-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200530-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200530-
Descrição: dc.descriptionThe development of gastroretentive systems have been growing lately due to the high demand for carriers that increase drug bioavailability and therapeutic effectiveness after oral administration. Most of systems reported up to now are based on chitosan (CS) due to its peculiar properties, such as cationic nature, biodegradability, biocompatibility and important mucoadhesiveness, which make CS a promising biopolymer to design effective gastroretentive systems. In light of this, we reported in this review the CS versatility to fabricate different types of nano- and microstructured gastroretentive systems. For a better understanding of the gastric retention mechanisms, we highlighted expandable, density-based, magnetic, mucoadhesive and superporous systems. The biological and chemical properties of CS, anatomophysiological aspects related to gastrointestinal tract (GIT) and some applications of these systems are also described here. Overall, this review may assist researchers to explore new strategies to design safe and efficient gastroretentive systems in order to popularize them in the treatment of diseases and clinical practices.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences Araraquara Department of Drugs and Medicines, Rodovia Araraquara-Jaú, km 1, - Campos Ville-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences Araraquara Department of Drugs and Medicines, Rodovia Araraquara-Jaú, km 1, - Campos Ville-
Descrição: dc.descriptionFAPESP: 2014/50928-2-
Descrição: dc.descriptionCNPq: 465687/2014-8-
Descrição: dc.descriptionCAPES: 88887.199954/2018-00-
Formato: dc.format804-822-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Biological Macromolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiopolymer-
Palavras-chave: dc.subjectChitosan-
Palavras-chave: dc.subjectDrug delivery systems-
Palavras-chave: dc.subjectGastroretentive systems-
Palavras-chave: dc.subjectStomach-
Título: dc.titleHighlighting the impact of chitosan on the development of gastroretentive drug delivery systems-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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